Detailed information of TA system TA021173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 29785..30410
• Replicon: plasmid pSCV50
• Accession: NC_006855
• Organism: Salmonella enterica subsp. enterica serovar Choleraesuis str.

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SCH_RS23470
• Protein ID: WP_000911322.1
• Coordinates: 30012..30410 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8F2UQ48
• Locus tag: SCH_RS23465
• Protein ID: WP_000450263.1
• Coordinates: 29785..30012 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCH_RS23435	25269..25424	-	156	WP_001719547.1	hypothetical protein	-
SCH_RS26810	25440..25713	-	274	Protein_34	disulfide bond formation protein DsbA	-
SCH_RS23445	25830..26393	-	564	WP_000139307.1	fertility inhibition protein FinO	-
SCH_RS23450	26448..27188	-	741	WP_000177630.1	conjugal transfer pilus acetylase TraX	-
SCH_RS23460	27208..29703	-	2496	Protein_37	conjugative relaxase	-
SCH_RS23465	29785..30012	+	228	WP_000450263.1	toxin-antitoxin system antitoxin VapB	Antitoxin
SCH_RS23470	30012..30410	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
SCH_RS23475	30419..32617	-	2199	WP_001541557.1	type IV conjugative transfer system coupling protein TraD	-
SCH_RS23480	32989..33720	-	732	WP_001541558.1	complement resistance protein TraT	-
SCH_RS24395	34023..34265	-	243	WP_024131413.1	hypothetical protein	-
SCH_RS23490	34262..34963	-	702	WP_148201696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49558	49558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T21173 WP_000911322.1 NC_006855:30012-30410 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T21173 NC_006855:30012-30410 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT21173 WP_000450263.1 NC_006855:29785-30012 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT21173 NC_006855:29785-30012 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA