Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798260..798917 Replicon chromosome
Accession NZ_CP080346
Organism Klebsiella pneumoniae strain K191659

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K0P51_RS03955 Protein ID WP_002916310.1
Coordinates 798507..798917 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K0P51_RS03950 Protein ID WP_002916312.1
Coordinates 798260..798526 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0P51_RS03925 (793416) 793416..794849 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
K0P51_RS03930 (794968) 794968..795696 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K0P51_RS03935 (795746) 795746..796057 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
K0P51_RS03940 (796221) 796221..796880 + 660 WP_002916317.1 hemolysin III family protein -
K0P51_RS03945 (797031) 797031..798014 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
K0P51_RS03950 (798260) 798260..798526 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K0P51_RS03955 (798507) 798507..798917 + 411 WP_002916310.1 protein YgfX Toxin
K0P51_RS03960 (798924) 798924..799445 - 522 WP_004144730.1 flavodoxin FldB -
K0P51_RS03965 (799546) 799546..800442 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K0P51_RS03970 (800465) 800465..801178 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K0P51_RS03975 (801184) 801184..802917 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T211725 WP_002916310.1 NZ_CP080346:798507-798917 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T211725 NZ_CP106754:c71700-71395 [Kosakonia sp. ML.JS2a]
ATGGAGAAAGGAACTCCCCATACCCGCTTACATATCGTTAAGCAAATGGTCACGGATGGAAAAATTAAGATAACGTCCAG
CGCAATCGCTGGCGCTATCGAACTCGGTTTTACCGTACCGCCCTTTGATGAAATGTGTACAGTCATTCTTAGCCTGACAA
TGACCGATTTTTTTAAAAGCATGACGGCATATGCCGATCACACTATTTGGCATGATGTCTATCGTCCATTGTGGAATGGG
CAAAGAATATACCTGAAATTAATCGTCTCGAACGACGTGCTGATCGTCTCGTTTAAGGAGAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT211725 WP_002916312.1 NZ_CP080346:798260-798526 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT211725 NZ_CP106754:c71393-70992 [Kosakonia sp. ML.JS2a]
ATGAAATGTCCTGTTTGCGGCGGTGCAGAACTCAAACATGAAACACGCGACGTCGCTTATGAGTACAAAAATCGTAAGAC
GTTGATAAAAAACGTTATGGGTGATTTTTGCGACAACTGCGGCGAAATTGTTTTTGACCGCATCAACGGTGAACATTACG
CAAAACAGGTTGCTGCGTTTGTACGCAATGTTAATGCCAATGAAGTCGATCCACACTTTATCGCCAGAGTACGTAAACGT
TTCAACCTTGACCAGCGCCAGGCTGCCGAGATTTTCGGTGGTGGCGCCAATGCATTCAGCCGCTACGAAACCGGACGTGT
TGCACCCCCTAAGCCCTTAATATTGCTGTTCAAGGCATTGGATAAACACCCCGAATTGTTTGAAGAACTAAAACATGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References