Detailed information of TA system TA021172

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 12831..13356
• Replicon: plasmid pSCV50
• Accession: NC_006855
• Organism: Salmonella enterica subsp. enterica serovar Choleraesuis str.

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: Q9EUE9
• Locus tag: SCH_RS23350
• Protein ID: WP_001541545.1
• Coordinates: 12831..13136 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: SCH_RS23355
• Protein ID: WP_000813641.1
• Coordinates: 13138..13356 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCH_RS23310	8233..8792	-	560	Protein_10	inverse autotransporter beta domain-containing protein	-
SCH_RS23320	9512..9997	-	486	WP_000905606.1	membrane protein	-
SCH_RS23325	9991..10500	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
SCH_RS23330	10427..11195	-	769	Protein_13	EAL domain-containing protein	-
SCH_RS23335	11204..11986	-	783	WP_000082169.1	site-specific integrase	-
SCH_RS23340	12021..12542	-	522	WP_000198608.1	hypothetical protein	-
SCH_RS23345	12539..12829	-	291	WP_001266176.1	hypothetical protein	-
SCH_RS23350	12831..13136	-	306	WP_001541545.1	type II toxin-antitoxin system toxin CcdB	Toxin
SCH_RS23355	13138..13356	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
SCH_RS23360	14032..14553	+	522	WP_011264020.1	hypothetical protein	-
SCH_RS27480	14597..15025	-	429	Protein_20	hypothetical protein	-
SCH_RS26800	15037..15332	+	296	Protein_21	cytoplasmic protein	-
SCH_RS23375	15826..16815	+	990	WP_000461383.1	RepB family plasmid replication initiator protein	-
SCH_RS26055	17104..17265	-	162	WP_001541548.1	hypothetical protein	-
SCH_RS23380	17318..17704	-	387	WP_001541549.1	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49558	49558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T21172 WP_001541545.1 NC_006855:c13136-12831 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T21172 NC_006855:c13136-12831 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT21172 WP_000813641.1 NC_006855:c13356-13138 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT21172 NC_006855:c13356-13138 [Salmonella enterica subsp. enterica serovar Choleraesuis str.]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: Q9EUE9

Antitoxin

• AlphaFold DB: A0A656ICA6