Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4955561..4956217 Replicon chromosome
Accession NZ_CP080333
Organism Mycolicibacterium pallens strain JCM 16370

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag K0O64_RS24100 Protein ID WP_096312225.1
Coordinates 4955561..4956007 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag K0O64_RS24105 Protein ID WP_220045809.1
Coordinates 4956011..4956217 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0O64_RS24075 (K0O64_24075) 4952268..4953152 + 885 WP_096312222.1 hypothetical protein -
K0O64_RS24080 (K0O64_24080) 4953149..4954036 - 888 WP_096312223.1 amidohydrolase family protein -
K0O64_RS24085 (K0O64_24085) 4954145..4954804 + 660 WP_071949331.1 response regulator transcription factor -
K0O64_RS24090 (K0O64_24090) 4954806..4955030 - 225 WP_225933532.1 hypothetical protein -
K0O64_RS24095 (K0O64_24095) 4955174..4955557 + 384 WP_096312224.1 hypothetical protein -
K0O64_RS24100 (K0O64_24100) 4955561..4956007 - 447 WP_096312225.1 SRPBCC family protein Toxin
K0O64_RS24105 (K0O64_24105) 4956011..4956217 - 207 WP_220045809.1 antitoxin Antitoxin
K0O64_RS24110 (K0O64_24110) 4956221..4958620 - 2400 WP_220045810.1 HAD-IC family P-type ATPase -
K0O64_RS24115 (K0O64_24115) 4958617..4960203 - 1587 WP_220045811.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(9-55)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16052.73 Da        Isoelectric Point: 10.1634

>T211718 WP_096312225.1 NZ_CP080333:c4956007-4955561 [Mycolicibacterium pallens]
MAKLSVSVDVPLPPEQAWQHASDLSRYKDWLTIHRVWRSKLPDTLEKGTVVESIVEVKGMPNRVKWEIVHFKAPEAMTLN
GAGVGGVKVKLIGKVRANDKDPNTSVVTMDVHLGGAALFGPIGMVVAGALKGDIKESLNRFVTVFAPS

Download         Length: 447 bp

>T211718 NZ_CP106749:c929410-928991 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7344.10 Da        Isoelectric Point: 5.0152

>AT211718 WP_220045809.1 NZ_CP080333:c4956217-4956011 [Mycolicibacterium pallens]
MGFLDKALGKTKEVLGSNADKVEQAIDKAGDIIDQKTQGKYSGTVDKVQDAAKNYVDSNRTDKGEQPN

Download         Length: 207 bp

>AT211718 NZ_CP106749:c929646-929410 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References