Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 4330219..4330745 Replicon chromosome
Accession NZ_CP080333
Organism Mycolicibacterium pallens strain JCM 16370

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag K0O64_RS21090 Protein ID WP_071942669.1
Coordinates 4330219..4330521 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag K0O64_RS21095 Protein ID WP_096312006.1
Coordinates 4330518..4330745 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0O64_RS21075 (K0O64_21075) 4325254..4328757 + 3504 WP_198044356.1 indolepyruvate ferredoxin oxidoreductase family protein -
K0O64_RS21080 (K0O64_21080) 4329015..4329248 + 234 Protein_4197 hypothetical protein -
K0O64_RS21085 (K0O64_21085) 4329473..4330021 - 549 WP_225933504.1 hypothetical protein -
K0O64_RS21090 (K0O64_21090) 4330219..4330521 - 303 WP_071942669.1 toxin Toxin
K0O64_RS21095 (K0O64_21095) 4330518..4330745 - 228 WP_096312006.1 ribbon-helix-helix protein, CopG family Antitoxin
K0O64_RS21100 (K0O64_21100) 4331232..4332527 + 1296 WP_174714139.1 helix-turn-helix transcriptional regulator -
K0O64_RS21105 (K0O64_21105) 4332888..4334114 + 1227 WP_225933505.1 hypothetical protein -
K0O64_RS21110 (K0O64_21110) 4334107..4334595 + 489 WP_096312007.1 DNA-binding protein -
K0O64_RS21115 (K0O64_21115) 4334607..4334885 - 279 WP_096312964.1 hypothetical protein -
K0O64_RS21120 (K0O64_21120) 4335025..4335330 + 306 WP_096312965.1 hypothetical protein -
K0O64_RS21125 (K0O64_21125) 4335327..4335638 + 312 WP_096312008.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4320081..4335638 15557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10398.96 Da        Isoelectric Point: 4.1775

>T211717 WP_071942669.1 NZ_CP080333:c4330521-4330219 [Mycolicibacterium pallens]
VIAPGDIAPRRDTSHEVYVVVLSNSIHLAADTGRVITCPFIPGEIPDAAMALVVRVEHPEGVALPELVQWLPVAALDEPI
GNIGTNALGDTASLVTALVT

Download         Length: 303 bp

>T211717 NZ_CP106745:c5150591-5150313 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8198.26 Da        Isoelectric Point: 7.1999

>AT211717 WP_096312006.1 NZ_CP080333:c4330745-4330518 [Mycolicibacterium pallens]
MAKDKVSITLDQDVLAKADADAKAAGLNRSELVEQALRHEHLRIALKSYTSTTVPALSIDDYAQRIYQANRASGL

Download         Length: 228 bp

>AT211717 NZ_CP106745:c5150301-5149996 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References