Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 919533..920177 Replicon chromosome
Accession NZ_CP080333
Organism Mycolicibacterium pallens strain JCM 16370

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0O64_RS04335 Protein ID WP_220046106.1
Coordinates 919533..919928 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0O64_RS04340 Protein ID WP_220046107.1
Coordinates 919929..920177 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0O64_RS04310 (K0O64_04310) 915211..915861 - 651 WP_220046102.1 nicotinamide riboside transporter PnuC -
K0O64_RS04315 (K0O64_04315) 915858..916892 - 1035 WP_225933618.1 hypothetical protein -
K0O64_RS04320 (K0O64_04320) 916984..917628 + 645 WP_220046103.1 NUDIX domain-containing protein -
K0O64_RS04325 (K0O64_04325) 917707..918957 + 1251 WP_220046104.1 cytochrome P450 -
K0O64_RS04330 (K0O64_04330) 919022..919447 + 426 WP_220046105.1 cupin domain-containing protein -
K0O64_RS04335 (K0O64_04335) 919533..919928 - 396 WP_220046106.1 type II toxin-antitoxin system VapC family toxin Toxin
K0O64_RS04340 (K0O64_04340) 919929..920177 - 249 WP_220046107.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K0O64_RS04345 (K0O64_04345) 920310..920507 + 198 WP_096312685.1 antitoxin Phd -
K0O64_RS04350 (K0O64_04350) 920504..920887 + 384 WP_071947609.1 type II toxin-antitoxin system death-on-curing family toxin -
K0O64_RS04355 (K0O64_04355) 920967..921545 + 579 WP_220046108.1 hypothetical protein -
K0O64_RS04360 (K0O64_04360) 921602..922513 + 912 WP_220046109.1 hypothetical protein -
K0O64_RS04365 (K0O64_04365) 922576..922839 + 264 WP_096309971.1 type II toxin-antitoxin system VapB family antitoxin -
K0O64_RS04370 (K0O64_04370) 922836..923234 + 399 WP_096309973.1 type II toxin-antitoxin system VapC family toxin -
K0O64_RS04375 (K0O64_04375) 923276..924934 + 1659 WP_125477387.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 878824..924934 46110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13742.64 Da        Isoelectric Point: 4.3280

>T211713 WP_220046106.1 NZ_CP080333:c919928-919533 [Mycolicibacterium pallens]
MAAGLLDTSVVIDWHDPAVADKLPDEMAISAITVAELAAGPLLASTAVEAAKRQSRLQEVESLIEPIPFDDRAARSYGLI
VAAAISEGGKPRSRFADLLIAATAHAHGLDFYSRNADDFAGLTDLVCVVAL

Download         Length: 396 bp

>T211713 NZ_CP106745:1658645-1659232 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGTGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9112.34 Da        Isoelectric Point: 8.9140

>AT211713 WP_220046107.1 NZ_CP080333:c920177-919929 [Mycolicibacterium pallens]
MAKTIPQRELRNENAKLINAVAAGETFVVTRHGEPVAELRPIQSARKTFITRDDLARVAGAGVRIDPDQFRRDLDATIDQ
SL

Download         Length: 249 bp

>AT211713 NZ_CP106745:1659299-1660153 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGACAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGCCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References