Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3492695..3493662 Replicon chromosome
Accession NZ_CP080332
Organism Mycolicibacterium diernhoferi strain ATCC 19340

Toxin (Protein)


Gene name pezT Uniprot ID A0A1Q4H8Z2
Locus tag K0O62_RS16610 Protein ID WP_073858187.1
Coordinates 3493081..3493662 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1Q4H933
Locus tag K0O62_RS16605 Protein ID WP_073858186.1
Coordinates 3492695..3493084 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0O62_RS16590 (K0O62_16590) 3488895..3489566 + 672 WP_073858258.1 glycoside hydrolase -
K0O62_RS16595 (K0O62_16595) 3489579..3491195 - 1617 WP_234800211.1 alkaline phosphatase family protein -
K0O62_RS28695 3491173..3491517 + 345 WP_234800212.1 hypothetical protein -
K0O62_RS16600 (K0O62_16600) 3491712..3492641 + 930 WP_073858185.1 lytic transglycosylase domain-containing protein -
K0O62_RS16605 (K0O62_16605) 3492695..3493084 + 390 WP_073858186.1 hypothetical protein Antitoxin
K0O62_RS16610 (K0O62_16610) 3493081..3493662 + 582 WP_073858187.1 zeta toxin family protein Toxin
K0O62_RS16615 (K0O62_16615) 3494029..3495204 + 1176 WP_073858188.1 metallophosphoesterase -
K0O62_RS16620 (K0O62_16620) 3495598..3496221 + 624 WP_073858189.1 hypothetical protein -
K0O62_RS16625 (K0O62_16625) 3496244..3497131 - 888 WP_073858190.1 SPFH domain-containing protein -
K0O62_RS16630 (K0O62_16630) 3497306..3497908 - 603 WP_073858191.1 energy-coupling factor transporter transmembrane protein EcfT -
K0O62_RS16635 (K0O62_16635) 3497905..3498600 - 696 WP_073858192.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-145)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21017.02 Da        Isoelectric Point: 8.1460

>T211712 WP_073858187.1 NZ_CP080332:3493081-3493662 [Mycolicibacterium diernhoferi]
VKRLDLVVGCNGAGKSTFIELTLAPLLPGSPVVNADEIARHRWPGAALEHAYEAARIAADTRAKLVALGESFIAETVFSH
PSKLDLIDAAHAAGYTVALHVVLIPEELAVERVRHRVQAGGHDVPEDKIRQRYQRLWHLVAVAATRADTTVFYDNSSRRG
PRIVARLNAGFPMGSPVWPDWTPDALTGIRPAQ

Download         Length: 582 bp

>T211712 NZ_CP106745:c1167174-1166992 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAAGGGAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13451.84 Da        Isoelectric Point: 4.7599

>AT211712 WP_073858186.1 NZ_CP080332:3492695-3493084 [Mycolicibacterium diernhoferi]
MANAADRVTRVAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSGRHSAARLKVEAALAGGLELSELTDEEGVVFDAEI
SAAIEESLADTDYGALLTARGITTVALDESGQIVQHRPDGSSSVLHAGR

Download         Length: 390 bp

>AT211712 NZ_CP106745:c1166945-1166517 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTTGCCGTTTTCTGCAGAGACTTGCCGGAGCT
GAACAGCTATGGCGACGACAAGGTCCACGCAATCGGCGAGGCAGTCGACGCCATCGAGTCGACCCTCTCGCTATACGTTG
ATCAGCGCCGAGAAATCCCCGCGGCCAGCCAGGCGCAACCAGGCGAGCGCGTTATCCATCTGCCGGCAGTTACCGTTGCG
AAGATCGCGCTCTGGAACGAAATGGTCCGTCGAGATATGCGAAAGGCTGACCTCTGCCGGCTTCTCGGGATCGCACAGAC
CCAGGGCGACAGGCTCGTCGACTTCCTCCACAACACTAAGATGGAGGCCATGGAGAACGCTCTATCCGCCCTCGGACTCC
GCCTCTCAGTGAATATCGAGGCAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4H8Z2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q4H933

References