Detailed information of TA system TA211710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 6045877..6046538
• Replicon: chromosome
• Accession: NZ_CP080330
• Organism: Pseudomonas sp. ArH3a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2T0I3N3
• Locus tag: K0P33_RS27780
• Protein ID: WP_054919606.1
• Coordinates: 6045877..6046056 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K0P33_RS27785
• Protein ID: WP_242152689.1
• Coordinates: 6046110..6046538 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0P33_RS27740 (K0P33_27640)	6040887..6042569	-	1683	WP_242152675.1	terminase	-
K0P33_RS27745 (K0P33_27645)	6042559..6043122	-	564	WP_242152678.1	hypothetical protein	-
K0P33_RS27750 (K0P33_27650)	6043162..6043617	-	456	WP_242152680.1	lysis protein	-
K0P33_RS27755 (K0P33_27655)	6043614..6044063	-	450	WP_242152683.1	structural protein P5	-
K0P33_RS27760 (K0P33_27660)	6044277..6044810	+	534	WP_242152686.1	hypothetical protein	-
K0P33_RS27765 (K0P33_27665)	6044877..6045068	-	192	WP_099236453.1	hypothetical protein	-
K0P33_RS27770 (K0P33_27670)	6045065..6045415	-	351	WP_099236454.1	hypothetical protein	-
K0P33_RS27775 (K0P33_27675)	6045415..6045786	-	372	WP_099236455.1	chemotaxis protein	-
K0P33_RS27780 (K0P33_27680)	6045877..6046056	+	180	WP_054919606.1	type II toxin-antitoxin system HicA family toxin	Toxin
K0P33_RS27785 (K0P33_27685)	6046110..6046538	+	429	WP_242152689.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K0P33_RS27790 (K0P33_27690)	6046635..6046850	-	216	WP_078826855.1	hypothetical protein	-
K0P33_RS27795 (K0P33_27695)	6046867..6047355	-	489	WP_242152692.1	hypothetical protein	-
K0P33_RS27810 (K0P33_27710)	6048274..6048618	-	345	WP_242152695.1	hypothetical protein	-
K0P33_RS27815 (K0P33_27715)	6048702..6049169	-	468	WP_242152697.1	hypothetical protein	-
K0P33_RS27820 (K0P33_27720)	6049319..6049906	-	588	WP_242152700.1	hypothetical protein	-
K0P33_RS27825 (K0P33_27725)	6050073..6051446	-	1374	WP_242152702.1	replicative DNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	6020402..6063072	42670

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (8-77)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6646.70 Da
• Isoelectric Point: 11.1475

>T211710 WP_054919606.1 NZ_CP080330:6045877-6046056 [Pseudomonas sp. ArH3a]
MKFSEFRRWLKAQGVTFEAGKGSHFKVIAPNGNRTTFADHGSKEMPEPTRKAIIKQLGL

Nucleotide

• Length: 180 bp

>T211710 NZ_CP106744:c5850785-5850507 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15825.91 Da
• Isoelectric Point: 4.5091

>AT211710 WP_242152689.1 NZ_CP080330:6046110-6046538 [Pseudomonas sp. ArH3a]
MYDYAIRFEQDDSASGLAVFCRDLPELNSYGDDKEHAIREALDAIESALSIYVDERRAIPEASAAQEGEHVIYLPAVTVA
KIVLWNSMMDRDMRKADLCRLLGVHQAQGDRLVDFLHTSKMEQLENALAALGKRLSVSVEAA

Nucleotide

• Length: 429 bp

>AT211710 NZ_CP106744:c5850495-5850190 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCCGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A2T0I3N3