Detailed information of TA system TA211708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 4042882..4043495
• Replicon: chromosome
• Accession: NZ_CP080330
• Organism: Pseudomonas sp. ArH3a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K0P33_RS18380
• Protein ID: WP_094952018.1
• Coordinates: 4042882..4043133 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K0P33_RS18385
• Protein ID: WP_094952019.1
• Coordinates: 4043130..4043495 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0P33_RS18380 (K0P33_18320)	4042882..4043133	+	252	WP_094952018.1	type II toxin-antitoxin system HicA family toxin	Toxin
K0P33_RS18385 (K0P33_18325)	4043130..4043495	+	366	WP_094952019.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K0P33_RS18390 (K0P33_18330)	4043504..4044685	-	1182	WP_094952020.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-
K0P33_RS18395 (K0P33_18335)	4044969..4045979	+	1011	WP_242150315.1	hypothetical protein	-
K0P33_RS18400 (K0P33_18340)	4046008..4047828	+	1821	WP_242150318.1	1-deoxy-D-xylulose-5-phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9527.08 Da
• Isoelectric Point: 9.6950

>T211708 WP_094952018.1 NZ_CP080330:4042882-4043133 [Pseudomonas sp. ArH3a]
VSKNEKLLAKLLNEHMAFTWPELVTLLHRLGYTQIEGAGSRVKFDIGDPSAMITLHRPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T211708 NZ_CP106744:c5587051-5586761 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13137.86 Da
• Isoelectric Point: 6.4809

>AT211708 WP_094952019.1 NZ_CP080330:4043130-4043495 [Pseudomonas sp. ArH3a]
VNNQLKHNGYIGSIEASLEDNCLFGKVLFIKALVSYEGKTVAELDAAFREAVDDYLATCHTLGQTPEKPCKGSFNVRVGH
DLHLAAALAAARKKVTLNDLTRQALDEFLQHHSADAYPAVG

Nucleotide

• Length: 366 bp

>AT211708 NZ_CP106744:c5587347-5587048 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA