Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1968966..1969581 | Replicon | chromosome |
| Accession | NZ_CP080330 | ||
| Organism | Pseudomonas sp. ArH3a | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | K0P33_RS08840 | Protein ID | WP_242154878.1 |
| Coordinates | 1969399..1969581 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | K0P33_RS08835 | Protein ID | WP_094951024.1 |
| Coordinates | 1968966..1969376 (-) | Length | 137 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0P33_RS08800 (K0P33_08785) | 1964032..1964949 | + | 918 | WP_242154873.1 | LysR family transcriptional regulator | - |
| K0P33_RS08805 (K0P33_08790) | 1964963..1965373 | + | 411 | WP_242154875.1 | fosfomycin resistance glutathione transferase | - |
| K0P33_RS08810 (K0P33_08795) | 1965428..1966069 | + | 642 | WP_094951029.1 | LysE family translocator | - |
| K0P33_RS08815 (K0P33_08800) | 1966189..1966716 | + | 528 | WP_094951028.1 | DUF4142 domain-containing protein | - |
| K0P33_RS08820 (K0P33_08805) | 1966770..1967195 | - | 426 | WP_094951027.1 | low affinity iron permease family protein | - |
| K0P33_RS08825 (K0P33_08810) | 1967373..1968155 | + | 783 | WP_242154877.1 | GNAT family N-acetyltransferase | - |
| K0P33_RS08830 (K0P33_08815) | 1968156..1968656 | - | 501 | WP_094951025.1 | methylated-DNA--[protein]-cysteine S-methyltransferase | - |
| K0P33_RS08835 (K0P33_08820) | 1968966..1969376 | - | 411 | WP_094951024.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K0P33_RS08840 (K0P33_08825) | 1969399..1969581 | - | 183 | WP_242154878.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K0P33_RS08845 (K0P33_08830) | 1969750..1970643 | - | 894 | WP_094951022.1 | LysR family transcriptional regulator | - |
| K0P33_RS08850 (K0P33_08835) | 1970739..1971902 | + | 1164 | WP_242154880.1 | MFS transporter | - |
| K0P33_RS08855 (K0P33_08840) | 1971899..1973098 | + | 1200 | WP_242154882.1 | MFS transporter | - |
| K0P33_RS08860 (K0P33_08845) | 1973083..1973391 | - | 309 | WP_094951019.1 | putative addiction module antidote protein | - |
| K0P33_RS08865 (K0P33_08850) | 1973394..1973686 | - | 293 | Protein_1747 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K0P33_RS08870 (K0P33_08855) | 1974002..1974307 | - | 306 | WP_094951018.1 | DUF6482 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6915.18 Da Isoelectric Point: 11.1875
>T211707 WP_242154878.1 NZ_CP080330:c1969581-1969399 [Pseudomonas sp. ArH3a]
VDSRYLIGHIVAHGWYLMRTRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKRILKQALLS
VDSRYLIGHIVAHGWYLMRTRGSHHHFKHPTKPGLVTIPHPKKDLLDKTAKRILKQALLS
Download Length: 183 bp
>T211707 NZ_CP106744:c5190566-5190219 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA
Antitoxin
Download Length: 137 a.a. Molecular weight: 14775.74 Da Isoelectric Point: 4.6121
>AT211707 WP_094951024.1 NZ_CP080330:c1969376-1968966 [Pseudomonas sp. ArH3a]
MLYPIAISTGDENHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPRAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQKEG
MLYPIAISTGDENHAWGVEVPDIPGCYSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPRAQKVTVHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQKEG
Download Length: 411 bp
>AT211707 NZ_CP106744:c5190827-5190576 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|