Detailed information of TA system TA211705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3303418..3304028
• Replicon: chromosome
• Accession: NZ_CP080328
• Organism: Halomonas piezotolerans strain HN2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KZJ51_RS15210
• Protein ID: WP_219862002.1
• Coordinates: 3303846..3304028 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KZJ51_RS15205
• Protein ID: WP_219862001.1
• Coordinates: 3303418..3303822 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZJ51_RS15190	3298461..3300065	-	1605	WP_275443411.1	type I-E CRISPR-associated protein Cse1/CasA	-
KZJ51_RS15195	3300283..3302946	-	2664	WP_219861999.1	CRISPR-associated helicase Cas3'	-
KZJ51_RS17800	3302933..3303187	-	255	Protein_2964	HD domain-containing protein	-
KZJ51_RS15205	3303418..3303822	-	405	WP_219862001.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KZJ51_RS15210	3303846..3304028	-	183	WP_219862002.1	type II toxin-antitoxin system HicA family toxin	Toxin
KZJ51_RS15215	3306083..3307516	-	1434	WP_219862005.1	PLP-dependent aminotransferase family protein	-
KZJ51_RS15220	3307691..3307903	+	213	WP_219862007.1	DUF1127 domain-containing protein	-
KZJ51_RS15225	3307890..3308759	+	870	WP_219862009.1	PhzF family phenazine biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6747.88 Da
• Isoelectric Point: 10.7304

>T211705 WP_219862002.1 NZ_CP080328:c3304028-3303846 [Halomonas piezotolerans]
VKSKDLIKEMEADGWYLDRVSGSHHVFKHPTKPGSVPVPHPKKDLPKGTIHNIRKLAGLR

Nucleotide

• Length: 183 bp

>T211705 NZ_CP106744:3902961-3903539 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCT
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
TCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGTTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14785.70 Da
• Isoelectric Point: 4.9474

>AT211705 WP_219862001.1 NZ_CP080328:c3303822-3303418 [Halomonas piezotolerans]
MQYPIAIEWGDEHTATGIVIPDIPGAVTAGDTTEHAYEMAVEVAHIQLEELANENKDIPMPRSIAEHRKNPDFEGYGWGI
IDIDITPYLGKTEKVNVTLPGHVIRQIDKYVTTHGIKSRSAFIASAALEKLNHA

Nucleotide

• Length: 405 bp

>AT211705 NZ_CP106744:3902318-3902872 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAATCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGCTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA