Detailed information of TA system TA211704

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 975888..976390
• Replicon: chromosome
• Accession: NZ_CP080328
• Organism: Halomonas piezotolerans strain HN2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KZJ51_RS04500
• Protein ID: WP_219863072.1
• Coordinates: 975888..976142 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6H1Y4Z8
• Locus tag: KZJ51_RS04505
• Protein ID: WP_039176654.1
• Coordinates: 976139..976390 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZJ51_RS04465	970964..972028	+	1065	WP_219863059.1	hypothetical protein	-
KZJ51_RS04470	972105..972737	+	633	WP_219863061.1	hypothetical protein	-
KZJ51_RS04475	972837..973211	+	375	WP_219863063.1	DUF4440 domain-containing protein	-
KZJ51_RS04480	973314..973940	+	627	WP_219863065.1	LysE family translocator	-
KZJ51_RS04485	974085..974318	+	234	WP_219863068.1	hypothetical protein	-
KZJ51_RS17730	974391..974554	+	164	Protein_878	transposase	-
KZJ51_RS04495	974688..975728	+	1041	WP_244992993.1	alpha/beta fold hydrolase	-
KZJ51_RS04500	975888..976142	-	255	WP_219863072.1	Txe/YoeB family addiction module toxin	Toxin
KZJ51_RS04505	976139..976390	-	252	WP_039176654.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KZJ51_RS04510	976554..977375	-	822	WP_219863074.1	aldo/keto reductase	-
KZJ51_RS04515	977571..978035	+	465	WP_219863076.1	OsmC family protein	-
KZJ51_RS04520	978141..978668	+	528	WP_244992994.1	GNAT family N-acetyltransferase	-
KZJ51_RS04525	978691..979161	+	471	WP_219863081.1	GNAT family N-acetyltransferase	-
KZJ51_RS04530	979205..979633	+	429	WP_219863083.1	GFA family protein	-
KZJ51_RS04535	979636..980094	+	459	WP_219863085.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10206.79 Da
• Isoelectric Point: 9.8162

>T211704 WP_219863072.1 NZ_CP080328:c976142-975888 [Halomonas piezotolerans]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEAKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T211704 NZ_CP106744:3753532-3753843 [Pseudomonas aeruginosa]
ATGCGAACAGTCATCGAAACTGAGATTTTCAAGCGCTATGCAGACGACATCTGGAGCGATCCCGAACGGGAGGAGTTCAT
AGCGTGGATTGCCGCCAATTCCCTAGCCGGAGATGTAATCCCAGGATCAGGCGGGCTTCGCAAGGTGCGCTGGTCTCGTC
CTGGCATGGGAAAGCGCGGAGGCGCGCGCGTGATCTATTACAACGCCGAAGAGGCGCAAGCCATCTGGCTACTGATAGCG
TACACAAAATCAAAGTTCGATAACCTACCAGCATCCACCTTGAGCAAATTGAAAGAGGCTATGAATGGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9280.52 Da
• Isoelectric Point: 4.4750

>AT211704 WP_039176654.1 NZ_CP080328:c976390-976139 [Halomonas piezotolerans]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Nucleotide

• Length: 252 bp

>AT211704 NZ_CP106744:3753836-3754114 [Pseudomonas aeruginosa]
ATGGATAAGGAACTTGAAACCTTCGAGGCCGATCTCCTCGCCTCGATTGACGAAATGAAGAAGGGGAAGGCTGCCCGTTC
GACGCACGTCGAACTTTCTCCGATTGCAGAGATTCGTGCAAAGGTTGGAATGGCGCAATCTGAGTTCGCACTCCTCCTGG
GAGTTAGCGTTCGTACTCTACAGGAATGGGAGCAGGGTAGAAGGTCTCCTTCTGGAGCAGCGAAAACCTTAATTAAGGTT
GCAAGCAAGCATCCAGAAACGCTTCGTGAACTGCGCTAG

Structures

Antitoxin

• AlphaFold DB: A0A6H1Y4Z8