Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1363..1943 Replicon plasmid p426-colRNAI
Accession NZ_CP080314
Organism Klebsiella pneumoniae strain KP-426

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag KZ481_RS29550 Protein ID WP_071177730.1
Coordinates 1363..1677 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag KZ481_RS29555 Protein ID WP_000093040.1
Coordinates 1665..1943 (-) Length 93 a.a.

Genomic Context

KZ481_RS29535KZ481_RS29575KZ481_RS29540KZ481_RS29545KZ481_RS29550KZ481_RS29555KZ481_RS29945KZ481_RS29565KZ481_RS29570
Location: 9..539 (531 bp)
Type: Others
Protein ID: WP_071177729.1
Location: 4015..5502 (1488 bp)
Type: Others
Protein ID: WP_004178082.1
Location: 566..745 (180 bp)
Type: Others
Protein ID: WP_000165970.1
Location: 771..1199 (429 bp)
Type: Others
Protein ID: WP_001140599.1
Location: 1363..1677 (315 bp)
Type: Toxin
Protein ID: WP_071177730.1
Location: 1665..1943 (279 bp)
Type: Antitoxin
Protein ID: WP_000093040.1
Location: 2118..2483 (366 bp)
Type: Others
Protein ID: WP_072354022.1
Location: 2480..2851 (372 bp)
Type: Others
Protein ID: WP_001237044.1
Location: 3125..3370 (246 bp)
Type: Others
Protein ID: WP_032440458.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KZ481_RS29535 (KZ481_29540)9..539+531WP_071177729.1hypothetical protein-
KZ481_RS29540 (KZ481_29545)566..745-180WP_000165970.1Rop family plasmid primer RNA-binding protein-
KZ481_RS29545 (KZ481_29550)771..1199-429WP_001140599.1hypothetical protein-
KZ481_RS29550 (KZ481_29555)1363..1677-315WP_071177730.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KZ481_RS29555 (KZ481_29560)1665..1943-279WP_000093040.1CopG family ribbon-helix-helix proteinAntitoxin
KZ481_RS299452118..2483-366WP_072354022.1TonB family protein-
KZ481_RS29565 (KZ481_29570)2480..2851-372WP_001237044.1cell envelope integrity protein TolA-
KZ481_RS29570 (KZ481_29575)3125..3370-246WP_032440458.1hypothetical protein-
KZ481_RS29575 (KZ481_29580)4015..5502+1488WP_004178082.1group II intron reverse transcriptase/maturase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..1197011970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T211703 WP_071177730.1 NZ_CP080314:c1677-1363 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T211703 NZ_CP106744:2808820-2809395 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAATCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAACGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT211703 WP_000093040.1 NZ_CP080314:c1943-1665 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT211703 NZ_CP106744:2808353-2808823 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2X1PRM1

References