Detailed information of TA system TA021170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1627697..1629279
• Replicon: chromosome
• Accession: NC_006840
• Organism: Vibrio fischeri ES114

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q5E4T1
• Locus tag: VF_RS07585
• Protein ID: WP_011262056.1
• Coordinates: 1627960..1629279 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: VF_RS07580
• Protein ID: WP_011262055.1
• Coordinates: 1627697..1627960 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VF_RS07565	1624259..1624681	+	423	WP_011262052.1	Hsp20 family protein	-
VF_RS07570	1624805..1626703	+	1899	WP_011262053.1	molecular chaperone DnaK	-
VF_RS07575	1626802..1627437	-	636	WP_011262054.1	hypothetical protein	-
VF_RS07580	1627697..1627960	+	264	WP_011262055.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
VF_RS07585	1627960..1629279	+	1320	WP_011262056.1	type II toxin-antitoxin system HipA family toxin	Toxin
VF_RS07590	1629688..1631259	-	1572	WP_011262057.1	cryptochrome/photolyase family protein	-
VF_RS07595	1631297..1631437	-	141	WP_193332956.1	DUF2256 domain-containing protein	-
VF_RS07600	1631647..1631922	+	276	WP_011262059.1	DUF3081 domain-containing protein	-
VF_RS07605	1631924..1632475	+	552	WP_011262060.1	CIA30 family protein	-
VF_RS07610	1632426..1633325	-	900	WP_011262061.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49372.79 Da
• Isoelectric Point: 7.0967

>T21170 WP_011262056.1 NC_006840:1627960-1629279 [Aliivibrio fischeri ES114]
MAILIAYMNGERVGEFTKLSNGAHQFQYDKSWIESTVGRPLSLSLPLQYPKITSDCVINYFDNLLPDLSEVRDRIVARYQ
AKSRQTFDLLHEVGKDSVGAISLLTNDEEPNTKQLDYEVLTPARLKQVLSAYQSNIPLGMLEDESDFRISVAGAQEKTAL
LRINNEWCIPKASTPTTHIIKLPIGKIQQPNATLDMSDSVENEYLCIQLAKKLGFNVPNVEIIHSDGIKAIAVERFDRRW
IKNNTKLLRLPQEDMCQAFGLPSSIKYEADGGPSIKTIMDLLMGSSQSLKDRDAFMRFQVFQWLIGATDGHAKNFSIFIN
AQGSYHLTPFYDILSAYPILGGKGMNIRSLKLAMGLTASKGKKYPIDKIYTRHFIDTAKAVGFDTARMEEIMKEFAINMP
NAIKELEAQLPSDFPKDISDSIFSNALRMVNKIRLSNDL

Nucleotide

• Length: 1320 bp

>T21170 NC_006840:1627960-1629279 [Aliivibrio fischeri ES114]
ATGGCTATATTAATTGCATACATGAATGGTGAGCGCGTTGGAGAATTTACTAAACTCAGTAACGGTGCACACCAGTTTCA
ATACGATAAATCATGGATTGAAAGCACGGTAGGAAGACCTCTTTCATTATCCCTCCCCCTACAGTATCCAAAGATAACCA
GTGATTGCGTTATTAATTACTTCGACAACCTATTACCTGATTTATCAGAAGTCAGAGATCGCATCGTTGCCAGATACCAA
GCTAAATCTCGTCAAACGTTCGATTTACTTCATGAAGTTGGAAAAGACAGCGTCGGTGCAATTTCTTTATTAACTAACGA
TGAAGAACCAAATACCAAACAACTGGATTATGAAGTTTTAACTCCAGCACGGCTCAAACAAGTACTCTCAGCCTATCAGT
CCAATATCCCATTAGGAATGTTAGAAGATGAATCAGACTTTCGAATTTCGGTTGCCGGAGCACAAGAAAAAACAGCATTA
CTCAGAATAAATAATGAATGGTGTATACCTAAGGCATCAACGCCAACAACACATATTATCAAATTACCCATAGGTAAAAT
TCAGCAACCTAATGCCACTCTCGATATGAGTGATAGTGTAGAAAATGAATACCTGTGCATCCAATTAGCGAAGAAGCTAG
GATTCAATGTACCTAATGTTGAAATAATTCATAGTGATGGAATAAAAGCCATTGCTGTAGAACGATTTGATAGACGATGG
ATTAAAAATAACACCAAGCTATTAAGATTACCGCAAGAAGATATGTGCCAAGCATTTGGATTGCCATCATCAATCAAATA
TGAAGCAGATGGAGGCCCAAGTATAAAAACCATTATGGATCTTCTAATGGGCTCAAGCCAATCACTAAAAGATCGTGATG
CTTTCATGCGATTTCAGGTATTTCAATGGTTAATCGGTGCAACAGATGGACACGCAAAAAACTTCTCCATTTTTATTAAT
GCACAAGGCAGTTATCACCTTACGCCCTTTTATGACATTTTATCCGCCTACCCAATCTTAGGTGGTAAAGGGATGAATAT
TCGCTCATTAAAACTAGCAATGGGACTAACAGCATCGAAAGGAAAGAAATACCCTATTGATAAAATATACACACGTCATT
TTATTGATACGGCTAAAGCTGTTGGATTTGATACTGCGAGAATGGAGGAAATAATGAAAGAATTTGCGATAAATATGCCT
AATGCCATTAAGGAATTAGAAGCACAATTACCAAGCGATTTTCCAAAAGATATCTCTGACAGCATATTCAGTAATGCTTT
GAGAATGGTAAATAAGATCCGCTTGAGTAATGATTTATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10009.54 Da
• Isoelectric Point: 6.7481

>AT21170 WP_011262055.1 NC_006840:1627697-1627960 [Aliivibrio fischeri ES114]
MMGCMMIYNPKQLANHLKLIRTKHNLTQTELAKKVGVKQSTLSSFENHPETTQLQTLFKILHALEVHCIIQEQVPASHED
NLDDEAW

Nucleotide

• Length: 264 bp

>AT21170 NC_006840:1627697-1627960 [Aliivibrio fischeri ES114]
ATGATGGGGTGTATGATGATTTATAATCCAAAGCAATTAGCTAACCACTTAAAGCTTATTAGAACCAAACACAATTTGAC
TCAAACAGAGCTTGCTAAAAAAGTTGGTGTAAAACAATCCACCCTATCTAGCTTTGAGAATCATCCTGAAACGACTCAGT
TACAGACACTCTTTAAGATCCTTCATGCATTAGAAGTTCATTGCATTATTCAAGAGCAAGTCCCAGCAAGTCACGAAGAC
AATCTAGACGATGAGGCGTGGTAA

Structures

Toxin

• AlphaFold DB: Q5E4T1