Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 74768..75678 | Replicon | plasmid p426-Vir |
| Accession | NZ_CP080310 | ||
| Organism | Klebsiella pneumoniae strain KP-426 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | KZ481_RS27435 | Protein ID | WP_004026354.1 |
| Coordinates | 74768..75238 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | KZ481_RS27440 | Protein ID | WP_004026357.1 |
| Coordinates | 75235..75678 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZ481_RS27395 (KZ481_27400) | 70084..70398 | + | 315 | WP_011251273.1 | hypothetical protein | - |
| KZ481_RS27400 (KZ481_27405) | 70407..70901 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| KZ481_RS27405 (KZ481_27410) | 70907..71347 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| KZ481_RS27410 (KZ481_27415) | 71772..72728 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| KZ481_RS27415 (KZ481_27420) | 72788..73129 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| KZ481_RS27420 (KZ481_27425) | 73143..73454 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| KZ481_RS27425 (KZ481_27430) | 73471..73920 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| KZ481_RS27435 (KZ481_27440) | 74768..75238 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| KZ481_RS27440 (KZ481_27445) | 75235..75678 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| KZ481_RS27445 (KZ481_27450) | 75779..76282 | - | 504 | Protein_90 | DUF4113 domain-containing protein | - |
| KZ481_RS27450 (KZ481_27455) | 76488..77468 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| KZ481_RS27455 (KZ481_27460) | 77534..78841 | + | 1308 | Protein_92 | FepA family TonB-dependent siderophore receptor | - |
| KZ481_RS27460 (KZ481_27465) | 78903..79124 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| KZ481_RS27465 (KZ481_27470) | 79267..80169 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| KZ481_RS27470 (KZ481_27475) | 80242..80643 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..188058 | 188058 | |
| - | inside | IScluster/Tn | - | iroN / rmpA | 68487..88463 | 19976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T211694 WP_004026354.1 NZ_CP080310:c75238-74768 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T211694 NZ_CP106743:c144003-143722 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT211694 WP_004026357.1 NZ_CP080310:c75678-75235 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT211694 NZ_CP106743:c144227-144000 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTATCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGCCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
ATGAGCACCGTAGTATCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGCCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |