Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4913778..4914294 Replicon chromosome
Accession NZ_CP080309
Organism Klebsiella pneumoniae strain KP-426

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KZ481_RS24330 Protein ID WP_002886902.1
Coordinates 4913778..4914062 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KZ481_RS24335 Protein ID WP_002886901.1
Coordinates 4914052..4914294 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ481_RS24305 (KZ481_24310) 4909262..4909525 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KZ481_RS24310 (KZ481_24315) 4909655..4909828 + 174 WP_002886906.1 hypothetical protein -
KZ481_RS24315 (KZ481_24320) 4909831..4910574 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KZ481_RS24320 (KZ481_24325) 4910931..4913069 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KZ481_RS24325 (KZ481_24330) 4913310..4913774 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZ481_RS24330 (KZ481_24335) 4913778..4914062 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ481_RS24335 (KZ481_24340) 4914052..4914294 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZ481_RS24340 (KZ481_24345) 4914372..4916282 - 1911 WP_004152270.1 PRD domain-containing protein -
KZ481_RS24345 (KZ481_24350) 4916305..4917459 - 1155 WP_002886900.1 lactonase family protein -
KZ481_RS24350 (KZ481_24355) 4917525..4918265 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T211689 WP_002886902.1 NZ_CP080309:c4914062-4913778 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211689 NZ_CP106742:2578505-2578795 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211689 WP_002886901.1 NZ_CP080309:c4914294-4914052 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211689 NZ_CP106742:2578209-2578508 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References