Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4197372..4197991 Replicon chromosome
Accession NZ_CP080309
Organism Klebsiella pneumoniae strain KP-426

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ481_RS20900 Protein ID WP_002892050.1
Coordinates 4197773..4197991 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ481_RS20895 Protein ID WP_002892066.1
Coordinates 4197372..4197746 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ481_RS20885 (KZ481_20890) 4192524..4193717 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ481_RS20890 (KZ481_20895) 4193740..4196886 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
KZ481_RS20895 (KZ481_20900) 4197372..4197746 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ481_RS20900 (KZ481_20905) 4197773..4197991 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ481_RS20905 (KZ481_20910) 4198150..4198716 + 567 WP_002892030.1 maltose O-acetyltransferase -
KZ481_RS20910 (KZ481_20915) 4198688..4198828 - 141 WP_004147370.1 hypothetical protein -
KZ481_RS20915 (KZ481_20920) 4198849..4199319 + 471 WP_002892026.1 YlaC family protein -
KZ481_RS20920 (KZ481_20925) 4199294..4200745 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KZ481_RS20925 (KZ481_20930) 4200846..4201544 + 699 WP_002892021.1 GNAT family protein -
KZ481_RS20930 (KZ481_20935) 4201541..4201681 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ481_RS20935 (KZ481_20940) 4201681..4201944 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211687 WP_002892050.1 NZ_CP080309:4197773-4197991 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T211687 NZ_CP106742:1593004-1593282 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT211687 WP_002892066.1 NZ_CP080309:4197372-4197746 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT211687 NZ_CP106742:1593294-1593599 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References