Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4911745..4912261 Replicon chromosome
Accession NZ_CP080303
Organism Klebsiella pneumoniae strain KP-CT77

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K0E63_RS24340 Protein ID WP_002886902.1
Coordinates 4911745..4912029 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K0E63_RS24345 Protein ID WP_002886901.1
Coordinates 4912019..4912261 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E63_RS24315 (K0E63_24315) 4907229..4907492 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K0E63_RS24320 (K0E63_24320) 4907622..4907795 + 174 WP_002886906.1 hypothetical protein -
K0E63_RS24325 (K0E63_24325) 4907798..4908541 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K0E63_RS24330 (K0E63_24330) 4908898..4911036 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K0E63_RS24335 (K0E63_24335) 4911277..4911741 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K0E63_RS24340 (K0E63_24340) 4911745..4912029 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0E63_RS24345 (K0E63_24345) 4912019..4912261 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K0E63_RS24350 (K0E63_24350) 4912339..4914249 - 1911 WP_004152270.1 PRD domain-containing protein -
K0E63_RS24355 (K0E63_24355) 4914272..4915426 - 1155 WP_002886900.1 lactonase family protein -
K0E63_RS24360 (K0E63_24360) 4915492..4916232 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T211659 WP_002886902.1 NZ_CP080303:c4912029-4911745 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211659 NZ_CP106680:c142494-142213 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211659 WP_002886901.1 NZ_CP080303:c4912261-4912019 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211659 NZ_CP106680:c142718-142491 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References