211643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2247..2721 Replicon plasmid unnamed1
Accession NZ_CP080302
Organism Klebsiella pneumoniae strain KP-C76

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag K0E64_RS29445 Protein ID WP_004197762.1
Coordinates 2455..2721 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag K0E64_RS29440 Protein ID WP_000879771.1
Coordinates 2247..2471 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E64_RS29825 383..817 + 435 Protein_1 relaxase/mobilization nuclease domain-containing protein -
K0E64_RS29430 (K0E64_29430) 852..1361 + 510 WP_032433972.1 MbeB family mobilization protein -
K0E64_RS29435 (K0E64_29435) 1368..1580 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
K0E64_RS29440 (K0E64_29440) 2247..2471 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
K0E64_RS29445 (K0E64_29445) 2455..2721 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0E64_RS29450 (K0E64_29450) 2791..3141 - 351 WP_004197756.1 hypothetical protein -
K0E64_RS29455 (K0E64_29455) 3207..3752 - 546 WP_023317533.1 hypothetical protein -
K0E64_RS29460 (K0E64_29460) 3778..4104 - 327 WP_050516389.1 hypothetical protein -
K0E64_RS29465 (K0E64_29465) 5260..5436 + 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T211643 WP_004197762.1 NZ_CP080302:2455-2721 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T211643 NZ_CP106660:c4043813-4042503 [Pantoea dispersa]
ATGACAGAACTGGATGTCTACATGAACGGCTATCGGACAGGCGTTTTCAGCAGGGCAGCAACCGGTGCACACACCTTCAG
ATATTATGAGAGCTGGCTGAATCAGCCGGGTAGCCGACCGATATCCCTCTCCATGCCTTTGCGCCACCAGCCTTACAAGG
GCGCGGAGGTCTATAACTTTTTTGATAACCTGCTGCCTGATAACCCTGAAATTCGCGCACGTATTCTGTCTCGCTATCAG
GCCAGCTCCACCCAGCCCTTTGACTTACTCGCAAAAGTCGGCAGCGACACCATTGGTGCGCTGCAATTGTTACCGCCTGA
CAGTAAACCGCACACTGTCCGAACGATCGATTACCGCAGGTTAAGCGATAGCGAACTGGAAAAAATCCTTTCAGGCTATC
AGTCAGGCGCACCGCTTGGCATGCTGGAAGAGCTAACGGATTTTCGTATTTCACTGGCTGGCGCGCAGGAGAAAACGGCG
CTGTTACGCATCGATCAACAATGGTGCCTGCCGCAGGGCAATACGCCCACCACCCATATTTTAAAATTGCCGATTGGCAA
TATTCAGAGCCATTCTCATCGCATCGATCTTTCAGATAGCGTGGAGAATGAGTGGCTTTGTACGCTGATTGCCAGAGAAT
TTGGCCTGGCAGTTCCCTCTTGCTTTATCGTAAACACCGGGAAAATTAAAGCACTGGCCGTGGAGCGGTTTGATCGGCGT
TATGCGTCGGATGGACAGTGGATCATGCGGTTACCCCAGGAAGATTTTTGTCAGGTGCTGAATGTACCCGCGGCAGGAAA
ATATGAAAGCCACGGCGGCCCGGGCATTTCTGCGATTATGGATTATCTCCTGAATTCAGTTAATGCAGAACAGGATCGAT
ATGATTTCATGAAAGCTCAGGTCCTGTTTTGGCTGCTGGCGGCCACCGATGGCCATGCCAAAAACTTTTCCATTTTTATC
GAAGCGGAAGGACGTTTTCGCCTGACGCCGTTTTACGACATTCTTTCCGTTTATCCCGTGATTGGCGGTGCGGGATTACA
CATTCGTGATGTAAAGCTGGCAATGGGACTGAACGGGAGCAAAGGCCGGAAAGCCGCCATCGAACACATTTTTCCCCGCC
ATTTTATAGAAACCGCAAAAACGACAAAATTTGCCCTGACGGCGATGGCACATATCCTCGATGAGTTCAGAGCCAGGACG
CCAGAAGTGATCCAACGCGTGCAGGAGCAAATCCCTGCAGCCTTCCCGTTACGCGTGAGCCAGACCATCCTCAATGGCTT
TAAGGCGCGGGCCGCGCGTCTGCAGCAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT211643 WP_000879771.1 NZ_CP080302:2247-2471 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT211643 NZ_CP106660:c4044070-4043813 [Pantoea dispersa]
ATGAAAATCACCAGCGCCAAACAATTAAGTTCTTATCTCAAAGATAGAAGACTCACAGAGTCACTCTCGCAAGCGAAAGT
CGCCAGCAAAATTGGGATTCGTCAGGATACCGTCTCGAGCTTTGAGCTACAGCCAGAAACCACCCGACTGGACACGCTGT
TTCGTATTCTCGCTGCTCTGGATCTGGAAATGGAGATAAAACCCCGTGGTTTGCCATCGGCCAAACAGGACCCGGACGGC
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References