Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4910953..4911469 Replicon chromosome
Accession NZ_CP080297
Organism Klebsiella pneumoniae strain KP-C76

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K0E64_RS24320 Protein ID WP_002886902.1
Coordinates 4910953..4911237 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K0E64_RS24325 Protein ID WP_002886901.1
Coordinates 4911227..4911469 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E64_RS24295 (K0E64_24295) 4906437..4906700 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K0E64_RS24300 (K0E64_24300) 4906830..4907003 + 174 WP_002886906.1 hypothetical protein -
K0E64_RS24305 (K0E64_24305) 4907006..4907749 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K0E64_RS24310 (K0E64_24310) 4908106..4910244 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K0E64_RS24315 (K0E64_24315) 4910485..4910949 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K0E64_RS24320 (K0E64_24320) 4910953..4911237 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K0E64_RS24325 (K0E64_24325) 4911227..4911469 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K0E64_RS24330 (K0E64_24330) 4911547..4913457 - 1911 WP_004152270.1 PRD domain-containing protein -
K0E64_RS24335 (K0E64_24335) 4913480..4914634 - 1155 WP_002886900.1 lactonase family protein -
K0E64_RS24340 (K0E64_24340) 4914700..4915440 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T211630 WP_002886902.1 NZ_CP080297:c4911237-4910953 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T211630 NZ_CP106658:2222764-2222867 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT211630 WP_002886901.1 NZ_CP080297:c4911469-4911227 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT211630 NZ_CP106658:c2222874-2222706 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References