Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2735291..2736879 | Replicon | chromosome |
| Accession | NZ_CP080297 | ||
| Organism | Klebsiella pneumoniae strain KP-C76 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | K0E64_RS13540 | Protein ID | WP_004199851.1 |
| Coordinates | 2735291..2736613 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | K0E64_RS13545 | Protein ID | WP_002904790.1 |
| Coordinates | 2736613..2736879 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K0E64_RS13525 (K0E64_13525) | 2730356..2732857 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| K0E64_RS13530 (K0E64_13530) | 2732845..2733849 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| K0E64_RS13535 (K0E64_13535) | 2733982..2735274 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| K0E64_RS13540 (K0E64_13540) | 2735291..2736613 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| K0E64_RS13545 (K0E64_13545) | 2736613..2736879 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| K0E64_RS13550 (K0E64_13550) | 2737145..2737471 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| K0E64_RS13555 (K0E64_13555) | 2737468..2737968 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| K0E64_RS13560 (K0E64_13560) | 2737946..2739325 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| K0E64_RS13565 (K0E64_13565) | 2739671..2740825 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| K0E64_RS13570 (K0E64_13570) | 2740806..2741729 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T211627 WP_004199851.1 NZ_CP080297:c2736613-2735291 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T211627 NZ_CP106658:c794715-794329 [Klebsiella michiganensis]
ATGCAAACGAAATTACCCTTCATGCGAGCGGCATCTTCACGTCCGTCTCCCGTTGATGTCTGGCAGACTCTCCTGACCTG
CCTGCTGGAACACCACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAGCAGGTCATTCAGCAACATATTGATG
CCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTCAGC
ATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGACAC
GTATAAAGAGGTGACGGCGATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA
ATGCAAACGAAATTACCCTTCATGCGAGCGGCATCTTCACGTCCGTCTCCCGTTGATGTCTGGCAGACTCTCCTGACCTG
CCTGCTGGAACACCACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAGCAGGTCATTCAGCAACATATTGATG
CCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTCAGC
ATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGACAC
GTATAAAGAGGTGACGGCGATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT211627 WP_002904790.1 NZ_CP080297:c2736879-2736613 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT211627 NZ_CP106658:c795098-794772 [Klebsiella michiganensis]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCCCCGTGTTTTGGTGCCCGACTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATGCAGATTTGCGCCATCTTGACCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGCCACCAGCATGGCGTCACGCTGTATGCA
AAAGGCCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATCCCGCTCCCGTCACCAC
AGAATAA
ATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCCCCGTGTTTTGGTGCCCGACTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATGCAGATTTGCGCCATCTTGACCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGCCACCAGCATGGCGTCACGCTGTATGCA
AAAGGCCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATCCCGCTCCCGTCACCAC
AGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |