Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2735291..2736879 Replicon chromosome
Accession NZ_CP080297
Organism Klebsiella pneumoniae strain KP-C76

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag K0E64_RS13540 Protein ID WP_004199851.1
Coordinates 2735291..2736613 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K0E64_RS13545 Protein ID WP_002904790.1
Coordinates 2736613..2736879 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E64_RS13525 (K0E64_13525) 2730356..2732857 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
K0E64_RS13530 (K0E64_13530) 2732845..2733849 + 1005 WP_004199852.1 fimbrial protein -
K0E64_RS13535 (K0E64_13535) 2733982..2735274 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K0E64_RS13540 (K0E64_13540) 2735291..2736613 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
K0E64_RS13545 (K0E64_13545) 2736613..2736879 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K0E64_RS13550 (K0E64_13550) 2737145..2737471 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K0E64_RS13555 (K0E64_13555) 2737468..2737968 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K0E64_RS13560 (K0E64_13560) 2737946..2739325 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
K0E64_RS13565 (K0E64_13565) 2739671..2740825 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K0E64_RS13570 (K0E64_13570) 2740806..2741729 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T211627 WP_004199851.1 NZ_CP080297:c2736613-2735291 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T211627 NZ_CP106658:c794715-794329 [Klebsiella michiganensis]
ATGCAAACGAAATTACCCTTCATGCGAGCGGCATCTTCACGTCCGTCTCCCGTTGATGTCTGGCAGACTCTCCTGACCTG
CCTGCTGGAACACCACTATGGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAGCAGGTCATTCAGCAACATATTGATG
CCGGTATCTCGCTGGTTGATGCCCTGAATTTTATCGTTGAGAAGTATGAACTGGTCCGCACTGACCGCCCAGGCTTCAGC
ATCCTGACGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGGAAAGCAACGGGGCTGATGAACCGTGACAC
GTATAAAGAGGTGACGGCGATTACCAGAGGGCAACATCCGCAGGTCAGCGCTCCAGGCAAGCGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT211627 WP_002904790.1 NZ_CP080297:c2736879-2736613 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT211627 NZ_CP106658:c795098-794772 [Klebsiella michiganensis]
ATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCCCCGTGTTTTGGTGCCCGACTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATGCAGATTTGCGCCATCTTGACCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGCCACCAGCATGGCGTCACGCTGTATGCA
AAAGGCCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATCCCGCTCCCGTCACCAC
AGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References