Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/MazF(toxin) |
Location | 881902..882457 | Replicon | chromosome |
Accession | NC_006582 | ||
Organism | Bacillus clausii KSM-K16 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | Q5WJV7 |
Locus tag | ABC_RS04245 | Protein ID | WP_011245664.1 |
Coordinates | 882107..882457 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A268RU80 |
Locus tag | ABC_RS04240 | Protein ID | WP_050748939.1 |
Coordinates | 881902..882102 (+) | Length | 67 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ABC_RS04215 | 877286..877870 | - | 585 | WP_142237599.1 | YitT family protein | - |
ABC_RS04220 | 878001..878762 | - | 762 | WP_011245659.1 | rhomboid family intramembrane serine protease | - |
ABC_RS04225 | 878886..879239 | + | 354 | WP_011245660.1 | holo-ACP synthase | - |
ABC_RS04230 | 879359..880381 | + | 1023 | WP_011245661.1 | outer membrane lipoprotein carrier protein LolA | - |
ABC_RS04235 | 880527..881759 | + | 1233 | WP_011245662.1 | alanine racemase | - |
ABC_RS04240 | 881902..882102 | + | 201 | WP_050748939.1 | hypothetical protein | Antitoxin |
ABC_RS04245 | 882107..882457 | + | 351 | WP_011245664.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
ABC_RS04250 | 882727..883545 | + | 819 | WP_011245665.1 | RsbT co-antagonist protein RsbRA | - |
ABC_RS04255 | 883563..883919 | + | 357 | WP_011245666.1 | STAS domain-containing protein | - |
ABC_RS04260 | 883922..884353 | + | 432 | WP_011245667.1 | anti-sigma regulatory factor | - |
ABC_RS04265 | 884354..885370 | + | 1017 | WP_011245668.1 | PP2C family protein-serine/threonine phosphatase | - |
ABC_RS04270 | 885435..885764 | + | 330 | WP_011245669.1 | STAS domain-containing protein | - |
ABC_RS04275 | 885764..886246 | + | 483 | WP_011245670.1 | anti-sigma B factor RsbW | - |
ABC_RS04280 | 886206..886991 | + | 786 | WP_011245671.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12845.93 Da Isoelectric Point: 9.6233
>T21162 WP_011245664.1 NC_006582:882107-882457 [Bacillus clausii KSM-K16]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEINASKYGFDRDSVILLEQV
RTIDKQRLTDKITHLDDKMMRSVDKALTISLGLIDF
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEINASKYGFDRDSVILLEQV
RTIDKQRLTDKITHLDDKMMRSVDKALTISLGLIDF
Download Length: 351 bp
>T21162 NC_006582:882107-882457 [Bacillus clausii KSM-K16]
GTGATAGTCAAACGCGGCGATGTGTATTTTGCAGATCTCTCCCCCGTTGTCGGCTCAGAACAAGGTGGGGTCAGGCCTGT
ACTCATCATACAAAATAATATCGGTAACCGATTTAGCCCGACAGTGATCGTAGCAGCTATTACAGCCCAAATCCAAAAAG
CAAAACTCCCAACACATGTGGAAATCAATGCGAGCAAATATGGGTTCGACCGGGATTCGGTCATTCTTCTTGAGCAAGTA
CGCACGATTGACAAACAACGACTGACAGATAAAATTACCCATCTTGACGACAAAATGATGAGGTCTGTTGACAAGGCACT
CACAATCAGTTTGGGATTAATTGATTTTTAG
GTGATAGTCAAACGCGGCGATGTGTATTTTGCAGATCTCTCCCCCGTTGTCGGCTCAGAACAAGGTGGGGTCAGGCCTGT
ACTCATCATACAAAATAATATCGGTAACCGATTTAGCCCGACAGTGATCGTAGCAGCTATTACAGCCCAAATCCAAAAAG
CAAAACTCCCAACACATGTGGAAATCAATGCGAGCAAATATGGGTTCGACCGGGATTCGGTCATTCTTCTTGAGCAAGTA
CGCACGATTGACAAACAACGACTGACAGATAAAATTACCCATCTTGACGACAAAATGATGAGGTCTGTTGACAAGGCACT
CACAATCAGTTTGGGATTAATTGATTTTTAG
Antitoxin
Download Length: 67 a.a. Molecular weight: 7509.42 Da Isoelectric Point: 4.4423
>AT21162 WP_050748939.1 NC_006582:881902-882102 [Bacillus clausii KSM-K16]
VDAVLEQEKWDNEENSNKRAKLKAEIRESMQQGYMEMAKINLTIASEAFLAEEEANHTLTRLVSGV
VDAVLEQEKWDNEENSNKRAKLKAEIRESMQQGYMEMAKINLTIASEAFLAEEEANHTLTRLVSGV
Download Length: 201 bp
>AT21162 NC_006582:881902-882102 [Bacillus clausii KSM-K16]
GTGGATGCTGTGCTTGAGCAGGAAAAGTGGGACAACGAAGAAAACAGCAATAAGCGTGCAAAACTAAAAGCTGAAATTCG
TGAGTCAATGCAACAAGGCTATATGGAGATGGCGAAAATCAATCTTACAATTGCATCAGAAGCCTTTCTTGCTGAGGAGG
AAGCGAATCATACGCTGACGCGTCTCGTTAGTGGGGTGTAG
GTGGATGCTGTGCTTGAGCAGGAAAAGTGGGACAACGAAGAAAACAGCAATAAGCGTGCAAAACTAAAAGCTGAAATTCG
TGAGTCAATGCAACAAGGCTATATGGAGATGGCGAAAATCAATCTTACAATTGCATCAGAAGCCTTTCTTGCTGAGGAGG
AAGCGAATCATACGCTGACGCGTCTCGTTAGTGGGGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q5WJV7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A268RU80 |