Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 1893918..1894548 Replicon chromosome
Accession NZ_CP080294
Organism Cupriavidus cauae strain PHS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ686_RS23695 Protein ID WP_265633873.1
Coordinates 1894138..1894548 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ686_RS23690 Protein ID WP_149316020.1
Coordinates 1893918..1894151 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ686_RS23675 (KZ686_23610) 1889117..1890037 + 921 WP_149316022.1 LysR substrate-binding domain-containing protein -
KZ686_RS23680 (KZ686_23615) 1890394..1891323 + 930 WP_265635403.1 tripartite tricarboxylate transporter substrate binding protein -
KZ686_RS23685 (KZ686_23620) 1891455..1893818 + 2364 WP_265633872.1 ATP-dependent DNA helicase -
KZ686_RS23690 (KZ686_23625) 1893918..1894151 + 234 WP_149316020.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KZ686_RS23695 (KZ686_23630) 1894138..1894548 + 411 WP_265633873.1 PIN domain-containing protein Toxin
KZ686_RS23700 (KZ686_23635) 1894564..1894782 - 219 WP_265633874.1 hypothetical protein -
KZ686_RS23705 (KZ686_23640) 1894862..1896292 - 1431 WP_265633875.1 aldehyde dehydrogenase family protein -
KZ686_RS23710 (KZ686_23645) 1896408..1897367 - 960 WP_149316017.1 tripartite tricarboxylate transporter substrate binding protein -
KZ686_RS23715 (KZ686_23650) 1897448..1898365 - 918 WP_149316016.1 dihydrodipicolinate synthase family protein -
KZ686_RS23720 (KZ686_23655) 1898467..1899360 + 894 WP_265633876.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-118)

Antitoxin

SpoVT-AbrB domain

(5-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15156.41 Da        Isoelectric Point: 5.1796

>T211613 WP_265633873.1 NZ_CP080294:1894138-1894548 [Cupriavidus cauae]
MREPKGSAFIDSNVVLYLLSEDARKANRSEALLRTRPTISVQVLNEVTSVCVRKLDMAWHEIADLVDAVKSFCTVVPLTV
DIHDSARRLAERHGFAFYDACIVATASMSGCQILYTEDMHDGLIVEDGLTIRNPFL

Download         Length: 411 bp

>T211613 NZ_CP106654:c3837905-3837588 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8733.96 Da        Isoelectric Point: 6.3479

>AT211613 WP_149316020.1 NZ_CP080294:1893918-1894151 [Cupriavidus cauae]
MQVAKWGNSLAVRLPSSVVEALELREGDDIEIVVDDPRTFAVRKKPGADVLLERVRQLRGRLPADFKFSRDEANERT

Download         Length: 234 bp

>AT211613 NZ_CP106654:c3837595-3837308 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References