Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1832330..1832859 Replicon chromosome
Accession NZ_CP080294
Organism Cupriavidus cauae strain PHS1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KZ686_RS23425 Protein ID WP_265633839.1
Coordinates 1832590..1832859 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KZ686_RS23420 Protein ID WP_149316065.1
Coordinates 1832330..1832593 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ686_RS23395 (KZ686_23330) 1827473..1828936 - 1464 WP_149316070.1 MFS transporter -
KZ686_RS23400 (KZ686_23335) 1829170..1829535 + 366 WP_149316069.1 TraR/DksA C4-type zinc finger protein -
KZ686_RS23405 (KZ686_23340) 1829554..1830684 - 1131 WP_265633837.1 NADH:flavin oxidoreductase -
KZ686_RS23410 (KZ686_23345) 1830681..1831079 - 399 WP_150083826.1 RidA family protein -
KZ686_RS23415 (KZ686_23350) 1831236..1832135 + 900 WP_265633838.1 LysR substrate-binding domain-containing protein -
KZ686_RS23420 (KZ686_23355) 1832330..1832593 + 264 WP_149316065.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KZ686_RS23425 (KZ686_23360) 1832590..1832859 + 270 WP_265633839.1 Txe/YoeB family addiction module toxin Toxin
KZ686_RS23430 (KZ686_23365) 1833052..1834374 - 1323 WP_149316063.1 oxalate/formate MFS antiporter -
KZ686_RS23435 (KZ686_23370) 1835162..1835854 + 693 WP_265633840.1 putative glycolipid-binding domain-containing protein -
KZ686_RS23440 (KZ686_23375) 1836234..1837052 + 819 WP_265635392.1 RNA polymerase sigma-70 factor -
KZ686_RS23445 (KZ686_23380) 1837150..1837629 + 480 WP_149316061.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10463.86 Da        Isoelectric Point: 8.8311

>T211612 WP_265633839.1 NZ_CP080294:1832590-1832859 [Cupriavidus cauae]
MTRHLTFMPAAWEDYIYWQGQDKKTLKRINALIQDAQRNPFEGLGKPEQLKGTLSGYRSRRIDDTNRLVYYANDDELAII
ACRLHYGDK

Download         Length: 270 bp

>T211612 NZ_CP106654:1875064-1875166 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9905.17 Da        Isoelectric Point: 6.0619

>AT211612 WP_149316065.1 NZ_CP080294:1832330-1832593 [Cupriavidus cauae]
MRTIHFSDARNNLKAVIDQAIADHDAILITRRDAPNAVIMSQEQYDSWMETMYLLSNPANAKRLMQSIDQHRSGKGVKHD
LIDPDAE

Download         Length: 264 bp

>AT211612 NZ_CP106654:c1875173-1875028 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References