211611

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 197967..198550 Replicon chromosome
Accession NZ_CP080294
Organism Cupriavidus cauae strain PHS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ686_RS16465 Protein ID WP_265634274.1
Coordinates 197967..198347 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ686_RS16470 Protein ID WP_265634276.1
Coordinates 198344..198550 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ686_RS16455 (KZ686_16415) 194574..196532 + 1959 WP_265634270.1 ATP-binding protein -
KZ686_RS16460 (KZ686_16420) 196529..197932 + 1404 WP_265634272.1 sigma-54 dependent transcriptional regulator -
KZ686_RS16465 (KZ686_16425) 197967..198347 - 381 WP_265634274.1 VapC toxin family PIN domain ribonuclease Toxin
KZ686_RS16470 (KZ686_16430) 198344..198550 - 207 WP_265634276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KZ686_RS16475 (KZ686_16435) 198714..199693 - 980 Protein_167 tripartite tricarboxylate transporter substrate binding protein -
KZ686_RS16480 (KZ686_16440) 199716..200651 - 936 WP_265634278.1 PhnD/SsuA/transferrin family substrate-binding protein -
KZ686_RS16485 (KZ686_16445) 200648..201649 - 1002 WP_265634280.1 ornithine cyclodeaminase family protein -
KZ686_RS16490 (KZ686_16450) 201766..202653 + 888 WP_265634282.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14030.44 Da        Isoelectric Point: 6.3177

>T211611 WP_265634274.1 NZ_CP080294:c198347-197967 [Cupriavidus cauae]
MSVLIDSSVWVDHFRHRNAALIDLIVMDQALTHPMVVAELACGTPPAPRLTTLNDIGLLQPCNQATLHEVMQFIERERLY
GLGCGLVDMVLLASTLITPSAKLWSLDKRLAELAERFGVAYQPRLH

Download         Length: 381 bp

>T211611 NZ_CP106654:810211-810621 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7561.69 Da        Isoelectric Point: 5.0941

>AT211611 WP_265634276.1 NZ_CP080294:c198550-198344 [Cupriavidus cauae]
MRTTVTIDDALYEKALEMADPGMDKSDLFREAIKTFVRVQAAKRLAALGGAAPDMEDVPRRREEPPAK

Download         Length: 207 bp

>AT211611 NZ_CP106654:809964-810230 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References