Detailed information of TA system TA211611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 197967..198550
• Replicon: chromosome
• Accession: NZ_CP080294
• Organism: Cupriavidus cauae strain PHS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KZ686_RS16465
• Protein ID: WP_265634274.1
• Coordinates: 197967..198347 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KZ686_RS16470
• Protein ID: WP_265634276.1
• Coordinates: 198344..198550 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14030.44 Da
• Isoelectric Point: 6.3177

>T211611 WP_265634274.1 NZ_CP080294:c198347-197967 [Cupriavidus cauae]
MSVLIDSSVWVDHFRHRNAALIDLIVMDQALTHPMVVAELACGTPPAPRLTTLNDIGLLQPCNQATLHEVMQFIERERLY
GLGCGLVDMVLLASTLITPSAKLWSLDKRLAELAERFGVAYQPRLH

Nucleotide

• Length: 381 bp

>T211611 NZ_CP106654:810211-810621 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7561.69 Da
• Isoelectric Point: 5.0941

>AT211611 WP_265634276.1 NZ_CP080294:c198550-198344 [Cupriavidus cauae]
MRTTVTIDDALYEKALEMADPGMDKSDLFREAIKTFVRVQAAKRLAALGGAAPDMEDVPRRREEPPAK

Nucleotide

• Length: 207 bp

>AT211611 NZ_CP106654:809964-810230 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA