Detailed information of TA system TA021161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 385957..386467
• Replicon: chromosome
• Accession: NC_006576
• Organism: Synechococcus elongatus PCC 6301 (Synechococcus leopoliensis SAG)

Toxin (Protein)

• Gene name: relB
• Uniprot ID: Q8KPS4
• Locus tag: SYC_RS01780
• Protein ID: WP_011242657.1
• Coordinates: 386204..386467 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q31NY1
• Locus tag: SYC_RS01775
• Protein ID: WP_011242656.1
• Coordinates: 385957..386211 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SYC_RS01735	382252..383259	-	1008	WP_011242649.1	acyl-CoA dehydrogenase family protein	-
SYC_RS01740	383285..383767	-	483	WP_173282542.1	glutathione peroxidase	-
SYC_RS01745	383919..384335	-	417	WP_011242651.1	type II toxin-antitoxin system VapC family toxin	-
SYC_RS01750	384339..384563	-	225	WP_039755738.1	hypothetical protein	-
SYC_RS01755	384715..384975	+	261	WP_011242652.1	DUF4160 domain-containing protein	-
SYC_RS01760	384980..385324	+	345	WP_011242653.1	DUF2442 domain-containing protein	-
SYC_RS01765	385324..385572	+	249	WP_011242654.1	DUF4160 domain-containing protein	-
SYC_RS01770	385575..385835	+	261	WP_011242655.1	DUF2442 domain-containing protein	-
SYC_RS01775	385957..386211	+	255	WP_011242656.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SYC_RS01780	386204..386467	+	264	WP_011242657.1	Txe/YoeB family addiction module toxin	Toxin
SYC_RS01785	386594..386869	-	276	WP_011242658.1	DUF2281 domain-containing protein	-
SYC_RS01790	386866..387030	-	165	WP_011377917.1	tyrosine-type recombinase/integrase	-
SYC_RS01795	387103..387345	+	243	WP_190528567.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SYC_RS01800	387342..387755	+	414	WP_011242660.1	type II toxin-antitoxin system VapC family toxin	-
SYC_RS01805	387843..390293	+	2451	WP_011242661.1	glycosyltransferase family 39 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10434.75 Da
• Isoelectric Point: 6.9760

>T21161 WP_011242657.1 NC_006576:386204-386467 [Synechococcus elongatus PCC 6301]
MRKLAWTNEAWEDYLYWQGQDKKTLNRINKLITETLRSPFEGIGKPEALRENLTGFWSRRIDDTNRLVYAVADDYLTIIS
CRYHYSD

Nucleotide

• Length: 264 bp

>T21161 NC_006576:386204-386467 [Synechococcus elongatus PCC 6301]
ATGCGTAAGCTGGCTTGGACAAACGAGGCTTGGGAAGATTACCTGTATTGGCAAGGGCAGGACAAGAAGACCTTAAATCG
CATCAACAAGCTCATTACCGAAACCTTGCGATCGCCCTTTGAGGGGATTGGTAAGCCAGAAGCGCTCAGGGAGAACCTGA
CTGGGTTTTGGTCACGCCGCATTGACGACACCAATCGCTTAGTTTACGCAGTAGCAGATGACTACCTGACCATTATTTCC
TGTCGCTACCACTACAGCGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9478.72 Da
• Isoelectric Point: 5.6400

>AT21161 WP_011242656.1 NC_006576:385957-386211 [Synechococcus elongatus PCC 6301]
MKVVSFSDARKNLKTVLDEVVNDADYTIITRRNAEEVVVMSLDSFNSLIETFHLLKSPANAAHLQRSIAQYQQGQTVERN
LLDA

Nucleotide

• Length: 255 bp

>AT21161 NC_006576:385957-386211 [Synechococcus elongatus PCC 6301]
ATGAAAGTTGTTTCCTTCAGTGACGCCAGAAAAAATCTCAAGACTGTCTTGGATGAAGTCGTCAACGACGCTGACTACAC
GATCATTACTCGCCGCAATGCCGAGGAGGTCGTGGTCATGTCCCTCGACTCCTTCAATAGCCTGATCGAAACCTTCCACC
TGCTCAAATCCCCTGCCAATGCTGCTCACCTACAACGCTCGATCGCTCAGTACCAGCAAGGTCAAACAGTCGAGCGAAAT
CTATTAGATGCGTAA

Structures

Toxin

• AlphaFold DB: Q8KPS4

Antitoxin

• AlphaFold DB: Q31NY1