Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2952635..2953855 Replicon chromosome
Accession NZ_CP080289
Organism Pseudomonas aeruginosa strain PA2207

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0E62_RS14185 Protein ID WP_003160088.1
Coordinates 2952635..2953213 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0E62_RS14190 Protein ID WP_003088112.1
Coordinates 2953301..2953855 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E62_RS14170 (K0E62_14165) 2947911..2949188 + 1278 WP_003102743.1 TolC family protein -
K0E62_RS14175 (K0E62_14170) 2949178..2951349 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
K0E62_RS14180 (K0E62_14175) 2951339..2952526 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
K0E62_RS14185 (K0E62_14180) 2952635..2953213 - 579 WP_003160088.1 HD domain-containing protein Toxin
K0E62_RS14190 (K0E62_14185) 2953301..2953855 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
K0E62_RS14195 (K0E62_14190) 2954013..2956208 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
K0E62_RS14200 (K0E62_14195) 2956213..2956674 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
K0E62_RS14205 (K0E62_14200) 2957005..2957328 + 324 WP_003102734.1 multidrug efflux SMR transporter -
K0E62_RS14210 (K0E62_14205) 2957341..2957739 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
K0E62_RS14215 (K0E62_14210) 2957736..2958287 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T211607 WP_003160088.1 NZ_CP080289:c2953213-2952635 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T211607 NZ_CP106652:526200-526550 [Bacillus safensis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTAGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211607 WP_003088112.1 NZ_CP080289:c2953855-2953301 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211607 NZ_CP106652:525914-526195 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAGTTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References