Detailed information of TA system TA211606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1949159..1950417
• Replicon: chromosome
• Accession: NZ_CP080289
• Organism: Pseudomonas aeruginosa strain PA2207

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: K0E62_RS09300
• Protein ID: WP_003112528.1
• Coordinates: 1949662..1950417 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: K0E62_RS09295
• Protein ID: WP_003086329.1
• Coordinates: 1949159..1949527 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K0E62_RS09275 (K0E62_09275)	1945322..1945597	+	276	WP_169057979.1	zinc ribbon domain-containing protein	-
K0E62_RS09280 (K0E62_09280)	1945600..1946076	-	477	WP_003112531.1	hypothetical protein	-
K0E62_RS09285 (K0E62_09285)	1946155..1947744	+	1590	WP_074231416.1	aldehyde dehydrogenase family protein	-
K0E62_RS09290 (K0E62_09290)	1947800..1949086	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
K0E62_RS09295 (K0E62_09295)	1949159..1949527	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
K0E62_RS09300 (K0E62_09300)	1949662..1950417	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
K0E62_RS09305 (K0E62_09305)	1951185..1952546	+	1362	WP_073647918.1	DNA recombination protein RmuC	-
K0E62_RS09310 (K0E62_09310)	1952701..1955244	-	2544	WP_031755663.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T211606 WP_003112528.1 NZ_CP080289:1949662-1950417 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211606 NZ_CP104992:4272472-4272660 [Rhizobium sp. CC-CFT758]
ATGAAGAGCGGCGATGTGATTGCGCGGCTGCGCGGGGATGGATGGTTCGAGGTGGCCCAGAGGGGCAGCCATATTCAATT
CAAGCATCCGACAAAGCCCGGACGGGTGACGGTGCCCCATCCAAAGCGCGACATCCCGATCGGCACGCTTCGAAGCATCG
AGAAGCAGGCCGGGCTGAAACTGAGGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211606 WP_003086329.1 NZ_CP080289:1949159-1949527 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211606 NZ_CP104992:4272663-4273067 [Rhizobium sp. CC-CFT758]
ATGAGCAACTATATCGGTCTTATCCACAAGGACGCCGACAGCGATTACGGTGTCTCCTTCCCAGATTTCCCTGGCATCGT
GACTGCCGGTACGACTCTCGACGAGGCGCGTCAGATGGCCGAGGAGGCCCTTGCCTTCCATGTCGACGGAATGATCGAAG
ACGGAGATGCCGTTCCCGAACCATCCAGCCTCGAAAACGTCATGGCCGATGAGACTAACCGGGATGGCGTTGCCATACTC
GTCACGTTGAAGACCCAGACCACGAAGGTGGTTCGCGTCAACATCACGCTGCCGGAAGATGTGCTGCAGACGATCGATGC
TTATGCAGAAGCCAATGGCCTTTCACGCTCCGGATTTCTGGCCCGGGCTGCCCGGCATGAGATCAAGCGCAGCAGCGCGG
CCTAG

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7