Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1874020..1874672 Replicon chromosome
Accession NZ_CP080289
Organism Pseudomonas aeruginosa strain PA2207

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K0E62_RS08890 Protein ID WP_003134109.1
Coordinates 1874262..1874672 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K0E62_RS08885 Protein ID WP_170869361.1
Coordinates 1874020..1874262 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0E62_RS08870 (K0E62_08870) 1869028..1870917 - 1890 WP_191519263.1 hypothetical protein -
K0E62_RS08875 (K0E62_08875) 1871029..1871775 - 747 WP_223723588.1 hypothetical protein -
K0E62_RS08880 (K0E62_08880) 1871789..1873714 - 1926 WP_191519261.1 type I DNA topoisomerase -
K0E62_RS08885 (K0E62_08885) 1874020..1874262 + 243 WP_170869361.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K0E62_RS08890 (K0E62_08890) 1874262..1874672 + 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
K0E62_RS08895 (K0E62_08895) 1874688..1874849 + 162 WP_191519260.1 hypothetical protein -
K0E62_RS08900 (K0E62_08900) 1874899..1875117 + 219 WP_023083218.1 hypothetical protein -
K0E62_RS08905 (K0E62_08905) 1875183..1875380 - 198 WP_191519259.1 CrpP family ICE-associated protein -
K0E62_RS08910 (K0E62_08910) 1875879..1876367 - 489 WP_023104904.1 single-stranded DNA-binding protein -
K0E62_RS08915 (K0E62_08915) 1876381..1876911 - 531 WP_121372660.1 DUF3158 family protein -
K0E62_RS08920 (K0E62_08920) 1876917..1877645 - 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
K0E62_RS32695 1877802..1878314 - 513 WP_223697281.1 hypothetical protein -
K0E62_RS08935 (K0E62_08935) 1878311..1879636 - 1326 WP_191519258.1 STY4528 family pathogenicity island replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 1766287..1893135 126848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T211605 WP_003134109.1 NZ_CP080289:1874262-1874672 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T211605 NZ_CP104992:c4266834-4266553 [Rhizobium sp. CC-CFT758]
ATGAGCTATAGGCTCGAATTCCTGCCATCGGCCCGCAAGGAATGGGACAAGCTCGGCGCCACATTGCGCGAGCAGTTCAG
GAAGAAGCTGGCGGAACGGCTCCTAAACCCCCGCGTCCCGCCGGATGCACTGCGCGGCATGGCCGATCACTACAAGATTA
AGTTGCGTACCGCAGGTTACCGACTCGTTTATCGCGTCGAGGATGAGAGGGTAACGGTCGTGGTCATCGCCGTTGGAAAG
CGGGAGCGTTCCGAGGTCTACGAGATTGCCAGGAATCGCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8909.94 Da        Isoelectric Point: 4.4230

>AT211605 WP_170869361.1 NZ_CP080289:1874020-1874262 [Pseudomonas aeruginosa]
MRCVVEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 243 bp

>AT211605 NZ_CP104992:c4266952-4266824 [Rhizobium sp. CC-CFT758]
ATGGCCTACATGGTACCGGCCGACACTTACGAGGCCATGATCGACGCTCTCGACGACCATGCACTGGTTGAAATCATCAA
GGCTCGTGCCGACGAGAAGGGCGTGCCGGTCGATATCGATGAGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References