Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5380824..5381481 Replicon chromosome
Accession NZ_CP080288
Organism Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag KZ800_RS24805 Protein ID WP_003098540.1
Coordinates 5380824..5381006 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KZ800_RS24810 Protein ID WP_004351284.1
Coordinates 5381053..5381481 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ800_RS24775 (KZ800_24770) 5375894..5377168 - 1275 WP_258169291.1 phage terminase large subunit family protein -
KZ800_RS28535 5377087..5377833 - 747 WP_258169284.1 phage terminase large subunit family protein -
KZ800_RS24780 (KZ800_24775) 5377823..5378350 - 528 WP_003128031.1 terminase small subunit -
KZ800_RS24785 (KZ800_24780) 5378482..5379225 - 744 WP_219832627.1 hypothetical protein -
KZ800_RS24790 (KZ800_24785) 5379222..5379671 - 450 WP_024082447.1 lysis system i-spanin subunit Rz -
KZ800_RS24795 (KZ800_24790) 5379692..5380309 - 618 WP_012613700.1 glycoside hydrolase family 19 protein -
KZ800_RS24800 (KZ800_24795) 5380309..5380623 - 315 WP_015649339.1 phage holin, lambda family -
KZ800_RS24805 (KZ800_24800) 5380824..5381006 + 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
KZ800_RS24810 (KZ800_24805) 5381053..5381481 + 429 WP_004351284.1 hypothetical protein Antitoxin
KZ800_RS24815 (KZ800_24810) 5381632..5382006 - 375 WP_219832628.1 antiterminator Q family protein -
KZ800_RS24820 (KZ800_24815) 5382008..5382304 - 297 WP_219832629.1 hypothetical protein -
KZ800_RS24825 (KZ800_24820) 5382301..5382882 - 582 WP_043884818.1 recombination protein NinG -
KZ800_RS24830 (KZ800_24825) 5382879..5383085 - 207 WP_031641812.1 hypothetical protein -
KZ800_RS24835 (KZ800_24830) 5383082..5383765 - 684 WP_124088989.1 replication protein P -
KZ800_RS24840 (KZ800_24835) 5383762..5384523 - 762 WP_047689501.1 helix-turn-helix domain-containing protein -
KZ800_RS24845 (KZ800_24840) 5385099..5385848 + 750 WP_223198354.1 XRE family transcriptional regulator -
KZ800_RS24850 (KZ800_24845) 5386185..5386460 + 276 WP_219832630.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5356286..5399336 43050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T211601 WP_003098540.1 NZ_CP080288:5380824-5381006 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T211601 NZ_CP104992:2492452-2492757 [Rhizobium sp. CC-CFT758]
ATGAAAGTCTATCGTCTAAGCCCGGCGGCTGAGGCGGATCTCGACGATATATGGAATTACACCATCATCAATTGGTCGCA
AGAACAAGCGGAACGCTATGTGTCCCGCCTTTTCGACAGCTTCATCAAACTTGGCGAAAATCCAAGTCTCGGCCGGAATG
CGAATTGGATCATGTCGGGTTATCGTCGCTTCAGATGCGGCCACCATCTGATATTCTACGTGACTGCCGATGACGGGCAG
GCGAATATTGTCCGCATCCTCCACGAAAAGGTCGATGTCCGCCGCCATTTCGATGACAAAGAATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15756.94 Da        Isoelectric Point: 4.6562

>AT211601 WP_004351284.1 NZ_CP080288:5381053-5381481 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKVHAIGEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT211601 NZ_CP104992:2492210-2492455 [Rhizobium sp. CC-CFT758]
ATGAACAAGCCCGTTCAAGTTACCATCGGTGAACCACTTGCCAGCTTTGTCGACAACGAAGTCGAGAGCGGCCGGTTTGC
GTCTCCGGACGAGGTCGTTGCGGCAGGCCTCCGCTTGCTTGAGGAAGAGCAGCAAAAACTTGAAAAGCTCCGTGAATTGC
TGATCGAGGGTGAGAACAGCGGCGAGCCGCGTCATGTTGATCGGGATGAATTTCTGGCGCGCATGCGCGAGAAACACGCT
CGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References