Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 5380824..5381481 | Replicon | chromosome |
| Accession | NZ_CP080288 | ||
| Organism | Pseudomonas aeruginosa strain UNC_PaerCF05 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A8G3IXE4 |
| Locus tag | KZ800_RS24805 | Protein ID | WP_003098540.1 |
| Coordinates | 5380824..5381006 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | KZ800_RS24810 | Protein ID | WP_004351284.1 |
| Coordinates | 5381053..5381481 (+) | Length | 143 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZ800_RS24775 (KZ800_24770) | 5375894..5377168 | - | 1275 | WP_258169291.1 | phage terminase large subunit family protein | - |
| KZ800_RS28535 | 5377087..5377833 | - | 747 | WP_258169284.1 | phage terminase large subunit family protein | - |
| KZ800_RS24780 (KZ800_24775) | 5377823..5378350 | - | 528 | WP_003128031.1 | terminase small subunit | - |
| KZ800_RS24785 (KZ800_24780) | 5378482..5379225 | - | 744 | WP_219832627.1 | hypothetical protein | - |
| KZ800_RS24790 (KZ800_24785) | 5379222..5379671 | - | 450 | WP_024082447.1 | lysis system i-spanin subunit Rz | - |
| KZ800_RS24795 (KZ800_24790) | 5379692..5380309 | - | 618 | WP_012613700.1 | glycoside hydrolase family 19 protein | - |
| KZ800_RS24800 (KZ800_24795) | 5380309..5380623 | - | 315 | WP_015649339.1 | phage holin, lambda family | - |
| KZ800_RS24805 (KZ800_24800) | 5380824..5381006 | + | 183 | WP_003098540.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KZ800_RS24810 (KZ800_24805) | 5381053..5381481 | + | 429 | WP_004351284.1 | hypothetical protein | Antitoxin |
| KZ800_RS24815 (KZ800_24810) | 5381632..5382006 | - | 375 | WP_219832628.1 | antiterminator Q family protein | - |
| KZ800_RS24820 (KZ800_24815) | 5382008..5382304 | - | 297 | WP_219832629.1 | hypothetical protein | - |
| KZ800_RS24825 (KZ800_24820) | 5382301..5382882 | - | 582 | WP_043884818.1 | recombination protein NinG | - |
| KZ800_RS24830 (KZ800_24825) | 5382879..5383085 | - | 207 | WP_031641812.1 | hypothetical protein | - |
| KZ800_RS24835 (KZ800_24830) | 5383082..5383765 | - | 684 | WP_124088989.1 | replication protein P | - |
| KZ800_RS24840 (KZ800_24835) | 5383762..5384523 | - | 762 | WP_047689501.1 | helix-turn-helix domain-containing protein | - |
| KZ800_RS24845 (KZ800_24840) | 5385099..5385848 | + | 750 | WP_223198354.1 | XRE family transcriptional regulator | - |
| KZ800_RS24850 (KZ800_24845) | 5386185..5386460 | + | 276 | WP_219832630.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5356286..5399336 | 43050 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6746.86 Da Isoelectric Point: 11.0775
>T211601 WP_003098540.1 NZ_CP080288:5380824-5381006 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK
Download Length: 183 bp
>T211601 NZ_CP104992:2492452-2492757 [Rhizobium sp. CC-CFT758]
ATGAAAGTCTATCGTCTAAGCCCGGCGGCTGAGGCGGATCTCGACGATATATGGAATTACACCATCATCAATTGGTCGCA
AGAACAAGCGGAACGCTATGTGTCCCGCCTTTTCGACAGCTTCATCAAACTTGGCGAAAATCCAAGTCTCGGCCGGAATG
CGAATTGGATCATGTCGGGTTATCGTCGCTTCAGATGCGGCCACCATCTGATATTCTACGTGACTGCCGATGACGGGCAG
GCGAATATTGTCCGCATCCTCCACGAAAAGGTCGATGTCCGCCGCCATTTCGATGACAAAGAATGA
ATGAAAGTCTATCGTCTAAGCCCGGCGGCTGAGGCGGATCTCGACGATATATGGAATTACACCATCATCAATTGGTCGCA
AGAACAAGCGGAACGCTATGTGTCCCGCCTTTTCGACAGCTTCATCAAACTTGGCGAAAATCCAAGTCTCGGCCGGAATG
CGAATTGGATCATGTCGGGTTATCGTCGCTTCAGATGCGGCCACCATCTGATATTCTACGTGACTGCCGATGACGGGCAG
GCGAATATTGTCCGCATCCTCCACGAAAAGGTCGATGTCCGCCGCCATTTCGATGACAAAGAATGA
Antitoxin
Download Length: 143 a.a. Molecular weight: 15756.94 Da Isoelectric Point: 4.6562
>AT211601 WP_004351284.1 NZ_CP080288:5381053-5381481 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKVHAIGEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKVHAIGEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA
Download Length: 429 bp
>AT211601 NZ_CP104992:2492210-2492455 [Rhizobium sp. CC-CFT758]
ATGAACAAGCCCGTTCAAGTTACCATCGGTGAACCACTTGCCAGCTTTGTCGACAACGAAGTCGAGAGCGGCCGGTTTGC
GTCTCCGGACGAGGTCGTTGCGGCAGGCCTCCGCTTGCTTGAGGAAGAGCAGCAAAAACTTGAAAAGCTCCGTGAATTGC
TGATCGAGGGTGAGAACAGCGGCGAGCCGCGTCATGTTGATCGGGATGAATTTCTGGCGCGCATGCGCGAGAAACACGCT
CGATGA
ATGAACAAGCCCGTTCAAGTTACCATCGGTGAACCACTTGCCAGCTTTGTCGACAACGAAGTCGAGAGCGGCCGGTTTGC
GTCTCCGGACGAGGTCGTTGCGGCAGGCCTCCGCTTGCTTGAGGAAGAGCAGCAAAAACTTGAAAAGCTCCGTGAATTGC
TGATCGAGGGTGAGAACAGCGGCGAGCCGCGTCATGTTGATCGGGATGAATTTCTGGCGCGCATGCGCGAGAAACACGCT
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|