Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5073360..5074868 Replicon chromosome
Accession NZ_CP080288
Organism Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KZ800_RS23335 Protein ID WP_003119682.1
Coordinates 5074281..5074868 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag KZ800_RS23330 Protein ID WP_003119683.1
Coordinates 5073360..5074214 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ800_RS23315 (KZ800_23310) 5068779..5068988 + 210 WP_003091604.1 cold-shock protein -
KZ800_RS23320 (KZ800_23315) 5069049..5070923 - 1875 WP_003091605.1 MFS transporter -
KZ800_RS23325 (KZ800_23320) 5071098..5073263 - 2166 WP_219832582.1 TonB-dependent receptor family protein -
KZ800_RS23330 (KZ800_23325) 5073360..5074214 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
KZ800_RS23335 (KZ800_23330) 5074281..5074868 - 588 WP_003119682.1 GNAT family protein Toxin
KZ800_RS23340 (KZ800_23335) 5075134..5078613 + 3480 WP_219832583.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T211600 WP_003119682.1 NZ_CP080288:c5074868-5074281 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T211600 NZ_CP104992:c2420537-2420268 [Rhizobium sp. CC-CFT758]
TTGGCCTGGAAGATTGACTTTCAGGCTACCGCGATCAAACAGCTCAAGAAGATGGGCCATAACGAGTCAGCTCGCATAAG
AGATTTCCTCCATACGAGGGTGAAGCCGCTCGACAATCCGCGCCAATTGGGCGAAGCCCTGCAAGGTCCTCGTTTTAAAC
ATCTCTGGCGATACAAGGTCGGCGATTACCGCATCATCTGCGACATTCAGGATGAGCGGCTCGTCGTCCTGGTAGTGGAA
GTTGACCACCGCCGCCAGATATACCGCTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT211600 WP_003119683.1 NZ_CP080288:c5074214-5073360 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT211600 NZ_CP104992:c2420751-2420521 [Rhizobium sp. CC-CFT758]
ATGAACAAGCGCGTCACGATCGAAATGCCGGACGAGATGCTGAAGCTCGTCGAGGAGTATGCGGCTGAAGCCGGTGCTGC
GCCGGATGCCTATCTGCGTGACGTGATTGAGCAGCATCTGGAGGATCTGCACGATATCGCGCTCGCCGAGGCGGCGATGG
AGCGCATTCGCAACGGCGAGCGAACCTATACCTGGGAAGAGATGGAGCGCGAACTTGGCCTGGAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References