211599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3504524..3505745 Replicon chromosome
Accession NZ_CP080288
Organism Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ800_RS16280 Protein ID WP_003114949.1
Coordinates 3504524..3505102 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ800_RS16285 Protein ID WP_003088112.1
Coordinates 3505191..3505745 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ800_RS16265 (KZ800_16265) 3499799..3501077 + 1279 Protein_3206 TolC family protein -
KZ800_RS16270 (KZ800_16270) 3501067..3503238 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
KZ800_RS16275 (KZ800_16275) 3503228..3504415 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KZ800_RS16280 (KZ800_16280) 3504524..3505102 - 579 WP_003114949.1 HD domain-containing protein Toxin
KZ800_RS16285 (KZ800_16285) 3505191..3505745 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KZ800_RS16290 (KZ800_16290) 3505904..3508099 - 2196 WP_219832416.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KZ800_RS16295 (KZ800_16295) 3508104..3508565 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
KZ800_RS16300 (KZ800_16300) 3508896..3509219 + 324 WP_003102734.1 multidrug efflux SMR transporter -
KZ800_RS16305 (KZ800_16305) 3509232..3509630 + 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
KZ800_RS16310 (KZ800_16310) 3509627..3510178 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T211599 WP_003114949.1 NZ_CP080288:c3505102-3504524 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T211599 NZ_CP104992:c1056393-1056100 [Rhizobium sp. CC-CFT758]
ATGAAGGCGCTTGTCTTCTCGCCCAAGGCTGAGGCCGATATCGACGATATTTACGACTATACCGAACAGCATTGGGGTTT
CGAGAATGCAGAGGTTTATACCTTTGAGCTCAGAGACGCCTGCCGATCTTTGGTCGAAGGGCCTCGACACGGTCGAAAGA
TTGGCGACGAGATAAGACGGAACTACTTCGTGCTGTCTTGCAAAGCTCATTTCATCATCTATCGGGAAACCGTAAGCCGG
ATCGTCATCGTGCGCATCCTCCATCAGCGCATGAACGTGCGACGCCATCTCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211599 WP_003088112.1 NZ_CP080288:c3505745-3505191 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211599 NZ_CP104992:c1056641-1056390 [Rhizobium sp. CC-CFT758]
GTGGGCGAGATCAAGTCGATCAAGGTGGACGAGGAACTGACGGCGTTCGTTAGGAAGCAGGTCGACGAAGGGCGCTATGC
GTCCGAAAGCGAGGTCGTCGAGGAGGCGCTAAGGCTGCTCAAGGAAAGCGAAGAGGAAGCTATCGAGGCGATCCGCACGG
CGATCGATGAGGGCGAGGCATCAGGAGAGCCGCAACCGTTCGATTTTGATGCTTTTATCGAACGTAAACGGGTACAGCGC
GCGCAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References