Detailed information of TA system TA211598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2571738..2572996
• Replicon: chromosome
• Accession: NZ_CP080288
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KZ800_RS11915
• Protein ID: WP_003449003.1
• Coordinates: 2572241..2572996 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KZ800_RS11910
• Protein ID: WP_003086329.1
• Coordinates: 2571738..2572106 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ800_RS11890 (KZ800_11895)	2567892..2568167	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
KZ800_RS11895 (KZ800_11900)	2568170..2568646	-	477	WP_003140638.1	hypothetical protein	-
KZ800_RS11900 (KZ800_11905)	2568725..2570323	+	1599	WP_219832975.1	aldehyde dehydrogenase family protein	-
KZ800_RS11905 (KZ800_11910)	2570379..2571665	+	1287	WP_219832977.1	FAD-binding oxidoreductase	-
KZ800_RS11910 (KZ800_11915)	2571738..2572106	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KZ800_RS11915 (KZ800_11920)	2572241..2572996	+	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
KZ800_RS11920 (KZ800_11925)	2573766..2575127	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
KZ800_RS11925 (KZ800_11930)	2575281..2577824	-	2544	WP_003123188.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T211598 WP_003449003.1 NZ_CP080288:2572241-2572996 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211598 NZ_CP104992:c300028-299690 [Rhizobium sp. CC-CFT758]
GTGAGCGCCGAGGAATACGTGCCGCAGGCAGGCGATATCGTCTGGCTCGATTTTTCGCCGCAAGTCGGTCATGAGCAGGC
CGGTCGCCGTCCCGCGGTCGTTCTCAGCCCGGTCGCCTATAATCGCTTCGGGCTGATGCTCTGCTGCCCCTTGACCACCA
AAGTGAAAGGCTACCCGTTCGAGGTCACCATTGAAGGTGGCCGGGGTGGCGTGGTCCTCGCGGACCAGGTCAAAAGTCTT
GACTGGAAAGCTCGTAATGCACAGCGCAAGGGCGCTGTGTCTTCGTCTGAACTCAGCCAAATCAGGGCCAAATCTTCGGC
CCTGATCGGTAGGCCTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211598 WP_003086329.1 NZ_CP080288:2571738-2572106 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211598 NZ_CP104992:c300267-300025 [Rhizobium sp. CC-CFT758]
ATGCGCGTGACCGTAAAAAAGTGGGGCAACAGTGCCTCGGTAAGAATTCCGGCCGCCATCATGGATGCGGCCAATCTGAC
TCTGGATACTGTTGTCGACATCACCGAGGAAAACGGCCGGGTCATCATCGAGCCGGTGCGTGAAGACGTGGTCGAGCTGG
ATCGGTTGCTTGGTGGCATCACGCCCGACAATCAGCATGACGAGATCGATTTTGGGGCACCTGTCGGCAAGGAAGCCCTG
TGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7