Detailed information of TA system TA211595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 561580..562121
• Replicon: chromosome
• Accession: NZ_CP080288
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KZ800_RS02685
• Protein ID: WP_219832766.1
• Coordinates: 561804..562121 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q9I707
• Locus tag: KZ800_RS02680
• Protein ID: WP_003112628.1
• Coordinates: 561580..561807 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ800_RS02655 (KZ800_02655)	556597..558090	+	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
KZ800_RS02660 (KZ800_02660)	558259..559686	+	1428	WP_003083784.1	GABA permease	-
KZ800_RS02665 (KZ800_02665)	559768..560109	-	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KZ800_RS02670 (KZ800_02670)	560183..560683	-	501	WP_003112629.1	LEA type 2 family protein	-
KZ800_RS02675 (KZ800_02675)	560784..561404	+	621	WP_003101226.1	hypothetical protein	-
KZ800_RS02680 (KZ800_02680)	561580..561807	+	228	WP_003112628.1	CopG family ribbon-helix-helix protein	Antitoxin
KZ800_RS02685 (KZ800_02685)	561804..562121	+	318	WP_219832766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ800_RS02690 (KZ800_02690)	562386..563294	+	909	WP_003083769.1	LysR family transcriptional regulator	-
KZ800_RS02695 (KZ800_02695)	563326..563736	-	411	WP_003101225.1	aegerolysin family protein	-
KZ800_RS02700 (KZ800_02700)	563916..564650	-	735	WP_003117208.1	GntR family transcriptional regulator	-
KZ800_RS02705 (KZ800_02705)	564751..565437	-	687	WP_219832767.1	FadR/GntR family transcriptional regulator	-
KZ800_RS02710 (KZ800_02710)	565486..566835	-	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11829.85 Da
• Isoelectric Point: 10.4079

>T211595 WP_219832766.1 NZ_CP080288:561804-562121 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITPLKVVTRLQDVSK

Nucleotide

• Length: 318 bp

>T211595 NZ_CP104986:c3907924-3906611 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTTGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTTGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8568.64 Da
• Isoelectric Point: 5.5740

>AT211595 WP_003112628.1 NZ_CP080288:561580-561807 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT211595 NZ_CP104986:c3908182-3907925 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: Q9I707