Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 561580..562121 Replicon chromosome
Accession NZ_CP080288
Organism Pseudomonas aeruginosa strain UNC_PaerCF05

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KZ800_RS02685 Protein ID WP_219832766.1
Coordinates 561804..562121 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KZ800_RS02680 Protein ID WP_003112628.1
Coordinates 561580..561807 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ800_RS02655 (KZ800_02655) 556597..558090 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
KZ800_RS02660 (KZ800_02660) 558259..559686 + 1428 WP_003083784.1 GABA permease -
KZ800_RS02665 (KZ800_02665) 559768..560109 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KZ800_RS02670 (KZ800_02670) 560183..560683 - 501 WP_003112629.1 LEA type 2 family protein -
KZ800_RS02675 (KZ800_02675) 560784..561404 + 621 WP_003101226.1 hypothetical protein -
KZ800_RS02680 (KZ800_02680) 561580..561807 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KZ800_RS02685 (KZ800_02685) 561804..562121 + 318 WP_219832766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ800_RS02690 (KZ800_02690) 562386..563294 + 909 WP_003083769.1 LysR family transcriptional regulator -
KZ800_RS02695 (KZ800_02695) 563326..563736 - 411 WP_003101225.1 aegerolysin family protein -
KZ800_RS02700 (KZ800_02700) 563916..564650 - 735 WP_003117208.1 GntR family transcriptional regulator -
KZ800_RS02705 (KZ800_02705) 564751..565437 - 687 WP_219832767.1 FadR/GntR family transcriptional regulator -
KZ800_RS02710 (KZ800_02710) 565486..566835 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11829.85 Da        Isoelectric Point: 10.4079

>T211595 WP_219832766.1 NZ_CP080288:561804-562121 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITPLKVVTRLQDVSK

Download         Length: 318 bp

>T211595 NZ_CP104986:c3907924-3906611 [Proteus mirabilis]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGCATCTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCCATCTCTCTTTCGATGCCATTACAGCTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAACTCAAATCAACCCTTTGACCTATTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
CAGTACGCCTGCGAATATCAAAAAAATAGAATATCAAAAACTCAATGATATTGAGCTTGAAAAAATTCTACTAGGATATA
AATCCAATACTCCACTTGGTATGCTTAAAGAATATACTGATTTCAGAATTTCCATCGCTGGAGCACAAGAAAAAACGGCA
TTACTTTTAAAAGATAATCATTGGTGTGTGCCACATAATAACACACCAACTACCCATATTATTAAACTGCCAATTGGTGT
TATTGAAAGTCATTCTTATACAATGGATTTATCCAATAGTGTAGAAAATGAGTATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCCGTCCCCCACTGCTCTATTATTAAAACAAAAAATGTTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TATTCATCTGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTTTAAATATACCTTCTGCGCTAAA
ATATGAAAATGAAGGAGGGCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGATCGTT
TTCATTTTATGAAGGCACAAGTGCTATTTTGGCTTTTGGCTGCAACGGATGGACACGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTCCATCTCACTCCCCTTTATGACATTATGTCCATCTATCCCAATTTCGGAGGACGAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGTC
ATTTCTACCAAACAGCTGAAGCTGTTGGTTTCGATCCTTCATTAATGAGCGATATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTCATACAACGCGTAAAACAGCAATTACCCGAGGATTTCCCTTCTGAGATTAGCAATACAATATTAGATGGAAT
GAAAGCACGCGCTGTTAGATTAGCTAACATTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT211595 WP_003112628.1 NZ_CP080288:561580-561807 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT211595 NZ_CP104986:c3908182-3907925 [Proteus mirabilis]
ATGATCATAATTAATGCCTATCAACTCAGTGTGCATCTAAAAGATGTCCGATTAACAAAAAAACTGTCTCAAAGTAAAGT
CGCCCAAAAAGTAGGGATCCGACAAGATACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCCGCACTAAATTTAGAGATGGAAATTCATCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References