Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5669675..5670932 Replicon chromosome
Accession NZ_CP080286
Organism Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)


Gene name - Uniprot ID A0A6A9JV85
Locus tag KZ795_RS26280 Protein ID WP_033969419.1
Coordinates 5669675..5670430 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag KZ795_RS26285 Protein ID WP_003086329.1
Coordinates 5670564..5670932 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ795_RS26270 (KZ795_26260) 5664844..5667387 + 2544 WP_121348809.1 acyl-homoserine-lactone acylase QuiP -
KZ795_RS26275 (KZ795_26265) 5667542..5668903 - 1362 WP_003134034.1 DNA recombination protein RmuC -
KZ795_RS26280 (KZ795_26270) 5669675..5670430 - 756 WP_033969419.1 RES family NAD+ phosphorylase Toxin
KZ795_RS26285 (KZ795_26275) 5670564..5670932 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
KZ795_RS26290 (KZ795_26280) 5671005..5672291 - 1287 WP_033969421.1 FAD-binding oxidoreductase -
KZ795_RS26295 (KZ795_26285) 5672347..5673936 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
KZ795_RS26300 (KZ795_26290) 5674015..5674491 + 477 WP_003112531.1 hypothetical protein -
KZ795_RS26305 (KZ795_26295) 5674494..5674769 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28253.37 Da        Isoelectric Point: 8.0554

>T211594 WP_033969419.1 NZ_CP080286:c5670430-5669675 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQATPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVNGKLPHPA

Download         Length: 756 bp

>T211594 NZ_CP104986:c3607315-3606896 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT211594 WP_003086329.1 NZ_CP080286:c5670932-5670564 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT211594 NZ_CP104986:c3607545-3607312 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGACAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A9JV85

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References