Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3144403..3145911 Replicon chromosome
Accession NZ_CP080286
Organism Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KZ795_RS14505 Protein ID WP_003119682.1
Coordinates 3144403..3144990 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag KZ795_RS14510 Protein ID WP_003091607.1
Coordinates 3145057..3145911 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ795_RS14500 (KZ795_14500) 3140658..3144137 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
KZ795_RS14505 (KZ795_14505) 3144403..3144990 + 588 WP_003119682.1 GNAT family protein Toxin
KZ795_RS14510 (KZ795_14510) 3145057..3145911 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
KZ795_RS14515 (KZ795_14515) 3146008..3148173 + 2166 WP_033968654.1 TonB-dependent receptor family protein -
KZ795_RS14520 (KZ795_14520) 3148348..3150222 + 1875 WP_033968656.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3150498..3151523 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T211592 WP_003119682.1 NZ_CP080286:3144403-3144990 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T211592 NZ_CP104976:4124033-4124554 [Enterobacter sp. 155105]
GTGAACGACGTGAAGATAGGGATTTTTTCAGAAGACGTTGAGTACGACCTAAGCCAGTTCGACTGCGGAGAAGAGAGCCT
TAATACCTTTCTGGCGGAGCACCTGAAACGCCAGCATCGTGGAAAGTTTTTGCGGGGTTATGTCCTCACCACACGAGAGC
CAAAACCGCGTATTCTGGGCTATTACACGCTCTCCGGAAGCTGTTTTGAAAAGGCTTACCTGCCCTCAAAAACTCAGCAA
AAACGTATTCCTTATAAAAATGTGCCGAGCGTCACCCTTGGCCGTCTGGCGATTGATAAACGTATTCAGGGGCAAGGCTA
TGGAGAATTACTCGTCATTCATGCCATGAAGACCGTTTATTTGGCCTCCTTTGCCGTCGGCATTCACGGCCTGTTTGTTG
AAGCACTCAACCATAAAGCCAAAGAGTTTTACCTCAAAATGGGGTTCATACCGCTCCTGGCCGAGAATGAATTCACGCTG
TTCTTACCGACTAAAACCTTTGAGAGCGTGTTTGAAGAGTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT211592 WP_003091607.1 NZ_CP080286:3145057-3145911 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT211592 NZ_CP104976:4123760-4124029 [Enterobacter sp. 155105]
ATGTCAGCACTGAAGAAACAGCGCATCGATCTCCGGTTAACCGAAGATGACAAAAACATGATCGAAGAAGCGGCGGCAAT
GACAAACCAGTCGATTTCACAATTCATGGTCAGCACAGCCTCTGAACGCGCAGCAGAGGTAATTGACCAGCACCGCCGCC
TGGTCCTTAGCGAAGCATCCTGGAATACGGTGATGGATGCCATCAGCAATCCGCCTGCGCCAAATGACCGCCTGAAGCGA
GCGGCTAAGCGTCTCCTGGATATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References