Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2576689..2577245 Replicon chromosome
Accession NZ_CP080286
Organism Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KZ795_RS11935 Protein ID WP_121348301.1
Coordinates 2576955..2577245 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L8EUQ8
Locus tag KZ795_RS11930 Protein ID WP_053244041.1
Coordinates 2576689..2576967 (+) Length 93 a.a.

Genomic Context

KZ795_RS11890KZ795_RS11895KZ795_RS11900KZ795_RS11905KZ795_RS11930KZ795_RS11935KZ795_RS11940KZ795_RS29320KZ795_RS29325KZ795_RS11950KZ795_RS11955KZ795_RS11960KZ795_RS11910KZ795_RS29315KZ795_RS11920KZ795_RS11925
Location: 2572440..2572673 (234 bp)
Type: Others
Protein ID: WP_105774685.1
Location: 2572670..2574130 (1461 bp)
Type: Others
Protein ID: WP_121348298.1
Location: 2574197..2574442 (246 bp)
Type: Others
Protein ID: WP_105774687.1
Location: 2574455..2574709 (255 bp)
Type: Others
Protein ID: WP_121348299.1
Location: 2576689..2576967 (279 bp)
Type: Antitoxin
Protein ID: WP_053244041.1
Location: 2576955..2577245 (291 bp)
Type: Toxin
Protein ID: WP_121348301.1
Location: 2577246..2577506 (261 bp)
Type: Others
Protein ID: WP_053244039.1
Location: 2577518..2577766 (249 bp)
Type: Others
Protein ID: Protein_2352
Location: 2577746..2577931 (186 bp)
Type: Others
Protein ID: WP_235488867.1
Location: 2577958..2578200 (243 bp)
Type: Others
Protein ID: WP_105774341.1
Location: 2578241..2579923 (1683 bp)
Type: Others
Protein ID: WP_196655782.1
Location: 2579920..2581668 (1749 bp)
Type: Others
Protein ID: WP_082308218.1
Location: 2574770..2575102 (333 bp)
Type: Others
Protein ID: WP_146122070.1
Location: 2575132..2575380 (249 bp)
Type: Others
Protein ID: WP_181155630.1
Location: 2575377..2576108 (732 bp)
Type: Others
Protein ID: WP_105774405.1
Location: 2576231..2576482 (252 bp)
Type: Others
Protein ID: WP_121348300.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KZ795_RS11890 (KZ795_11890)2572440..2572673+234WP_105774685.1entry exclusion lipoprotein TrbK-
KZ795_RS11895 (KZ795_11895)2572670..2574130+1461WP_121348298.1P-type conjugative transfer protein TrbL-
KZ795_RS11900 (KZ795_11900)2574197..2574442+246WP_105774687.1type I toxin-antitoxin system ptaRNA1 family toxin-
KZ795_RS11905 (KZ795_11905)2574455..2574709+255WP_121348299.1hypothetical protein-
KZ795_RS11910 (KZ795_11910)2574770..2575102-333WP_146122070.1hypothetical protein-
KZ795_RS293152575132..2575380-249WP_181155630.1hypothetical protein-
KZ795_RS11920 (KZ795_11920)2575377..2576108-732WP_105774405.1recombinase family protein-
KZ795_RS11925 (KZ795_11925)2576231..2576482-252WP_121348300.1hypothetical protein-
KZ795_RS11930 (KZ795_11930)2576689..2576967+279WP_053244041.1CopG family ribbon-helix-helix proteinAntitoxin
KZ795_RS11935 (KZ795_11935)2576955..2577245+291WP_121348301.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KZ795_RS11940 (KZ795_11940)2577246..2577506+261WP_053244039.1hypothetical protein-
KZ795_RS293202577518..2577766+249Protein_2352XRE family transcriptional regulator-
KZ795_RS293252577746..2577931+186WP_235488867.1hypothetical protein-
KZ795_RS11950 (KZ795_11950)2577958..2578200+243WP_105774341.1hypothetical protein-
KZ795_RS11955 (KZ795_11955)2578241..2579923+1683WP_196655782.1hypothetical protein-
KZ795_RS11960 (KZ795_11960)2579920..2581668+1749WP_082308218.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10862.51 Da        Isoelectric Point: 9.5296

>T211591 WP_121348301.1 NZ_CP080286:2576955-2577245 [Pseudomonas aeruginosa]
VSRLIWTPPALADVLRLYRFLAPKDANAAQRAVQAIRAGVKILAHQPRIGRPVEDMETEFREWLIDFGNGGYVALYRFDG
ENIAILAVRHQKEAGY

Download         Length: 291 bp

>T211591 NZ_CP104976:3619175-3619393 [Enterobacter sp. 155105]
ATGTCTGATAAACCACTCACAAAGTTCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TAACAATGAATAAGCTGTATGACAAAATTCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10747.06 Da        Isoelectric Point: 5.6306

>AT211591 WP_053244041.1 NZ_CP080286:2576689-2576967 [Pseudomonas aeruginosa]
MATATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEDYQRTGQHLTLEEADAWLAKLE
AGEDAELPKCHV

Download         Length: 279 bp

>AT211591 NZ_CP104976:3618773-3619147 [Enterobacter sp. 155105]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAATGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGACT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTGTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0L8EUQ8

References