Detailed information of TA system TA211591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2576689..2577245
• Replicon: chromosome
• Accession: NZ_CP080286
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KZ795_RS11935
• Protein ID: WP_121348301.1
• Coordinates: 2576955..2577245 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0L8EUQ8
• Locus tag: KZ795_RS11930
• Protein ID: WP_053244041.1
• Coordinates: 2576689..2576967 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ795_RS11890 (KZ795_11890)	2572440..2572673	+	234	WP_105774685.1	entry exclusion lipoprotein TrbK	-
KZ795_RS11895 (KZ795_11895)	2572670..2574130	+	1461	WP_121348298.1	P-type conjugative transfer protein TrbL	-
KZ795_RS11900 (KZ795_11900)	2574197..2574442	+	246	WP_105774687.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
KZ795_RS11905 (KZ795_11905)	2574455..2574709	+	255	WP_121348299.1	hypothetical protein	-
KZ795_RS11910 (KZ795_11910)	2574770..2575102	-	333	WP_146122070.1	hypothetical protein	-
KZ795_RS29315	2575132..2575380	-	249	WP_181155630.1	hypothetical protein	-
KZ795_RS11920 (KZ795_11920)	2575377..2576108	-	732	WP_105774405.1	recombinase family protein	-
KZ795_RS11925 (KZ795_11925)	2576231..2576482	-	252	WP_121348300.1	hypothetical protein	-
KZ795_RS11930 (KZ795_11930)	2576689..2576967	+	279	WP_053244041.1	CopG family ribbon-helix-helix protein	Antitoxin
KZ795_RS11935 (KZ795_11935)	2576955..2577245	+	291	WP_121348301.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ795_RS11940 (KZ795_11940)	2577246..2577506	+	261	WP_053244039.1	hypothetical protein	-
KZ795_RS29320	2577518..2577766	+	249	Protein_2352	XRE family transcriptional regulator	-
KZ795_RS29325	2577746..2577931	+	186	WP_235488867.1	hypothetical protein	-
KZ795_RS11950 (KZ795_11950)	2577958..2578200	+	243	WP_105774341.1	hypothetical protein	-
KZ795_RS11955 (KZ795_11955)	2578241..2579923	+	1683	WP_196655782.1	hypothetical protein	-
KZ795_RS11960 (KZ795_11960)	2579920..2581668	+	1749	WP_082308218.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10862.51 Da
• Isoelectric Point: 9.5296

>T211591 WP_121348301.1 NZ_CP080286:2576955-2577245 [Pseudomonas aeruginosa]
VSRLIWTPPALADVLRLYRFLAPKDANAAQRAVQAIRAGVKILAHQPRIGRPVEDMETEFREWLIDFGNGGYVALYRFDG
ENIAILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T211591 NZ_CP104976:3619175-3619393 [Enterobacter sp. 155105]
ATGTCTGATAAACCACTCACAAAGTTCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TAACAATGAATAAGCTGTATGACAAAATTCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10747.06 Da
• Isoelectric Point: 5.6306

>AT211591 WP_053244041.1 NZ_CP080286:2576689-2576967 [Pseudomonas aeruginosa]
MATATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEDYQRTGQHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT211591 NZ_CP104976:3618773-3619147 [Enterobacter sp. 155105]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAATGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGACT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTGTCCTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0L8EUQ8