Detailed information of TA system TA211590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1400041..1400546
• Replicon: chromosome
• Accession: NZ_CP080286
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KZ795_RS06385
• Protein ID: WP_033977365.1
• Coordinates: 1400041..1400322 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: KZ795_RS06390
• Protein ID: WP_003083775.1
• Coordinates: 1400319..1400546 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ795_RS06360 (KZ795_06360)	1395291..1396640	+	1350	WP_073648652.1	C4-dicarboxylate transporter DctA	-
KZ795_RS06365 (KZ795_06365)	1396690..1397376	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
KZ795_RS06370 (KZ795_06370)	1397477..1398211	+	735	WP_003117208.1	GntR family transcriptional regulator	-
KZ795_RS06375 (KZ795_06375)	1398391..1398801	+	411	WP_003110659.1	aegerolysin family protein	-
KZ795_RS06380 (KZ795_06380)	1398833..1399741	-	909	WP_073648653.1	LysR family transcriptional regulator	-
KZ795_RS06385 (KZ795_06385)	1400041..1400322	-	282	WP_033977365.1	type II toxin-antitoxin system toxin ParE	Toxin
KZ795_RS06390 (KZ795_06390)	1400319..1400546	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
KZ795_RS06395 (KZ795_06395)	1400722..1401342	-	621	WP_033968139.1	hypothetical protein	-
KZ795_RS06400 (KZ795_06400)	1401443..1401943	+	501	WP_003101228.1	LEA type 2 family protein	-
KZ795_RS06405 (KZ795_06405)	1402016..1402357	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KZ795_RS06410 (KZ795_06410)	1402441..1403868	-	1428	WP_121348755.1	GABA permease	-
KZ795_RS06415 (KZ795_06415)	1404037..1405530	-	1494	WP_023115963.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10459.19 Da
• Isoelectric Point: 9.6558

>T211590 WP_033977365.1 NZ_CP080286:c1400322-1400041 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T211590 NZ_CP104976:3493626-3493937 [Enterobacter sp. 155105]
ATGCACGTAGTCTCAAGAGCGCCTTTCGACACGGCCACCAGACAATTTCCTAATCAAGCACTCGCCCTGGGCGATCTTTA
CCGGGTGCTAAAGAAGGAACACTACCCGTCACCGGACGATATGAGAAAGCGATTCCCCAGCCTGGACAGGATGAAATACA
GGGAAAAATGGTGGGTCATTGATGTGGGTGGCGGGCATTTAAGAGTGATGTTTTTAGCTGATTTTGAACGAGGAAAGATC
TTCATCAAACACATCAGCACACACGCAGAGTATGACAAGCTCACGGAACTCTACCGGAGAACGAAAGAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT211590 WP_003083775.1 NZ_CP080286:c1400546-1400319 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT211590 NZ_CP104976:3493934-3494353 [Enterobacter sp. 155105]
ATGAATTATGCAGCAGCCATCAAAGCGGCAAACGATCTGACCAACGAGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGACA
AGATTACGAGGATGCGCTAGCGCTGGTGGAGTATCTGGTCGAACACGAACCCGATAGCTCGCTGGTAGAGATGCTCACCG
CCAAAATCGATAAATACGAAAACGAGTCTCCGGAGTTTGCAGAATTTAACTCACGTGTTGCCAGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATAGACCAGTACCAACTCACTCAGAGCGACTTTGAGAACGAGATTGGTAAAAAGTCTCTGGT
GAGTCGGATCCTTAACGGACAGCGTACGCTAACGCTGGATCATATGCGCGCGCTGGCGAAGCGTTTTGATTTGCCGGTGA
GTGCGTTTGTGGGGAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9