Detailed information of TA system TA211587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5280961..5282219
• Replicon: chromosome
• Accession: NZ_CP080285
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF14

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: KZ796_RS24250
• Protein ID: WP_003449003.1
• Coordinates: 5280961..5281716 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KZ796_RS24255
• Protein ID: WP_003086329.1
• Coordinates: 5281851..5282219 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ796_RS24240 (KZ796_24230)	5276129..5278672	+	2544	WP_003123188.1	acyl-homoserine-lactone acylase QuiP	-
KZ796_RS24245 (KZ796_24235)	5278827..5280188	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
KZ796_RS24250 (KZ796_24240)	5280961..5281716	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
KZ796_RS24255 (KZ796_24245)	5281851..5282219	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KZ796_RS24260 (KZ796_24250)	5282292..5283578	-	1287	WP_219832977.1	FAD-binding oxidoreductase	-
KZ796_RS24265 (KZ796_24255)	5283634..5285225	-	1592	Protein_4803	aldehyde dehydrogenase family protein	-
KZ796_RS24270 (KZ796_24260)	5285304..5285780	+	477	WP_003140638.1	hypothetical protein	-
KZ796_RS24275 (KZ796_24265)	5285783..5286058	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T211587 WP_003449003.1 NZ_CP080285:c5281716-5280961 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211587 NZ_CP104976:757106-757516 [Enterobacter sp. 155105]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCATGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTCTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATCAATGCACGTCAGGGAGAGATTAAATTGCTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGTAAGGTGGATGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGATCTGCGCCGGATGTTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211587 WP_003086329.1 NZ_CP080285:c5282219-5281851 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211587 NZ_CP104976:756859-757125 [Enterobacter sp. 155105]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAATCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7