Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4347714..4348935 Replicon chromosome
Accession NZ_CP080285
Organism Pseudomonas aeruginosa strain UNC_PaerCF14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ796_RS19890 Protein ID WP_003114949.1
Coordinates 4348357..4348935 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ796_RS19885 Protein ID WP_003088112.1
Coordinates 4347714..4348268 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ796_RS19860 (KZ796_19855) 4343281..4343832 + 552 WP_003102727.1 XRE family transcriptional regulator -
KZ796_RS19865 (KZ796_19860) 4343829..4344227 - 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
KZ796_RS19870 (KZ796_19865) 4344240..4344563 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KZ796_RS19875 (KZ796_19870) 4344894..4345355 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KZ796_RS19880 (KZ796_19875) 4345360..4347555 + 2196 WP_219832416.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KZ796_RS19885 (KZ796_19880) 4347714..4348268 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KZ796_RS19890 (KZ796_19885) 4348357..4348935 + 579 WP_003114949.1 HD domain-containing protein Toxin
KZ796_RS19895 (KZ796_19890) 4349044..4350231 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KZ796_RS19900 (KZ796_19895) 4350221..4352392 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
KZ796_RS19905 (KZ796_19900) 4352382..4353660 - 1279 Protein_3937 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T211586 WP_003114949.1 NZ_CP080285:4348357-4348935 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T211586 NZ_CP104973:3704076-3704360 [Phyllobacterium zundukense]
ATGATCCTGACTTATCGTGACAAGCGGACAGAAGCATTTGCCCGTGGAGAGTTTGTCCGCGAGTTTCAAGGATTTGAGCG
CCAGGCGTATAAACGGTTGGAAATCCTTGAAGCGGCAACAAGCCTGGCAGAACTTCGCATGCTGCCGAGTAACCGCCTCG
AAGCGTTGAAAGGCGATAAGAGCGGACAATTCAGTATCAGGATCAACATGCAATGGCGAATTTGTTTCGAATGGCCTGCG
AGCGCAGCAGGCCCTTCGGATGTCGCAATCATCGACTATCATTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211586 WP_003088112.1 NZ_CP080285:4347714-4348268 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211586 NZ_CP104973:3704373-3704657 [Phyllobacterium zundukense]
ATGCCTCGTCCAGCTATTCATCCCGGCGAAATTCTGGCCGACGAACTTGGCGAACTGAATATCAAACCAACCGAGTTGTC
GAGGCAAATCAATGTTCCTCCCAATCGGATAACACAAATCATTCATGGGAAGCGCGCTATAACCGGTGATACCGCCGTCC
GCTTGGGCCACTGGTTCGGAACCAGTGCGCAGTTCTGGCTCAATCTTCAAAGTGCCTATGACATTCGCTTGGCTGAAGAA
AAGTCGGGGGCCGAAATCGCCCTTCTTCCAACACGGTTGCAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References