Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2777932..2779440 Replicon chromosome
Accession NZ_CP080285
Organism Pseudomonas aeruginosa strain UNC_PaerCF14

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KZ796_RS12845 Protein ID WP_003119682.1
Coordinates 2777932..2778519 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag KZ796_RS12850 Protein ID WP_003119683.1
Coordinates 2778586..2779440 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ796_RS12840 (KZ796_12840) 2774187..2777666 - 3480 WP_219832583.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
KZ796_RS12845 (KZ796_12845) 2777932..2778519 + 588 WP_003119682.1 GNAT family protein Toxin
KZ796_RS12850 (KZ796_12850) 2778586..2779440 + 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
KZ796_RS12855 (KZ796_12855) 2779537..2781702 + 2166 WP_219832582.1 TonB-dependent receptor family protein -
KZ796_RS12860 (KZ796_12860) 2781877..2783751 + 1875 WP_003091605.1 MFS transporter -
KZ796_RS12865 (KZ796_12865) 2783812..2784021 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T211585 WP_003119682.1 NZ_CP080285:2777932-2778519 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T211585 NZ_CP104973:2703235-2703414 [Phyllobacterium zundukense]
ATGCCTAAGCCAGAGATCGTTGCGCGGCTAGAAGCCGAGGGATGGATCAATGTCGGTGGTGGCAATCACGACCGTTTTAT
CCATAAGGATAGACCGGAGCTCATGATTCCAGTACCCCGTCACCGCGAATTGTCTCCTGGAACGGCGAGATCCATCGCGA
AGGCAGCGGGTTGGATGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT211585 WP_003119683.1 NZ_CP080285:2778586-2779440 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT211585 NZ_CP104973:2703463-2703858 [Phyllobacterium zundukense]
ATGACCTATTATGTTGGAATACTGGATGGAACCGGTGCTGTCTGGGGTGTACGCATTCCAGATGTTTCTGGCTGTGTTGG
GGCAGGGGCGAGCCCCGAACAGGCAATTGCTGACGTGACAATCGCTCTTCGCGACGTGATGGCCCATAGGCGTGGAGGCG
GCTTCGAGATACCGGCCCCATCCTCGGTCTCAGCCATTCTTGCGTCAGGTGAAATTCAAGCCGGCGAAACGATCGTTATG
ATTCCACTGGTCCTTGATTCCGGGCGAACAGTACGTGCCAATCTCACGATGGATGCGGGATTGCTGGATGCTATTGATGA
GGCGGCGACGCTTCGCGGTGTGACTCGTTCCGCCTTTGTCGCGAGCGCAGCGCGGGAAAAAATTGAGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References