Detailed information of TA system TA211582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5960123..5961381
• Replicon: chromosome
• Accession: NZ_CP080281
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF17

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: KZ799_RS27475
• Protein ID: WP_003112528.1
• Coordinates: 5960123..5960878 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: KZ799_RS27480
• Protein ID: WP_003086329.1
• Coordinates: 5961013..5961381 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ799_RS27465 (KZ799_27455)	5955296..5957839	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
KZ799_RS27470 (KZ799_27460)	5957994..5959355	-	1362	WP_073647918.1	DNA recombination protein RmuC	-
KZ799_RS27475 (KZ799_27465)	5960123..5960878	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
KZ799_RS27480 (KZ799_27470)	5961013..5961381	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
KZ799_RS27485 (KZ799_27475)	5961454..5962740	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
KZ799_RS27490 (KZ799_27480)	5962796..5964385	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
KZ799_RS27495 (KZ799_27485)	5964464..5964940	+	477	WP_003112531.1	hypothetical protein	-
KZ799_RS27500 (KZ799_27490)	5964943..5965218	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T211582 WP_003112528.1 NZ_CP080281:c5960878-5960123 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T211582 NZ_CP104973:c2232155-2231757 [Phyllobacterium zundukense]
ATGCTACGGTATATGCTGGATACAAATATCTGCATTTACGTAATGAAAAGCTATCCTCTTCAATTGCGGGAGAAGTTCAA
TGCACTCGCGGAACAGCTATGCATATCCAGCATCACACTCGGCGAAATGCATTATGGGACGGAGAAATCAGCTCGCACCG
TTGAAAATTTGAAAGCGATCGAACACTTCGTCAGCCGGCTCGAAGTATTGCCTTTCGCTGCAGGTGCGGCAGTGCACTAC
GGACAGATACGTGCGGACCTTGAACGAGCCGGAACTCCGTGCGGATCGCATGATATGCAGATAGGTGGTCACGCGCGCAG
CGAAGGACTGGTTGTTGTGACCAACAATATGCGCGAATTTATACGCATGCCCGGGGTCTTGACCGAGAACTGGATTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT211582 WP_003086329.1 NZ_CP080281:c5961381-5961013 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT211582 NZ_CP104973:c2232388-2232155 [Phyllobacterium zundukense]
ATGACCAGCTCCACCGTTTTTACGACCAATCGCAGTCAGGCCGTCCGCTTGCCGAAAGCAGTCGCTTTTCCCGAAGACGT
GCACCAAGTGGATATCCTTAAGATCGGCCAGGGTCGTCTTGTGGTTCCTCAAGGCAAGCGTTGGGATGATCTTTTTACGC
AGGGACCGCGTTTGAGCGACGACTTTATGAGTGAACGCGAACAGCCTGTAATCGAAGATCGCGAGCCGCTTTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7