Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5024977..5026198 Replicon chromosome
Accession NZ_CP080281
Organism Pseudomonas aeruginosa strain UNC_PaerCF17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ799_RS23065 Protein ID WP_003114949.1
Coordinates 5025620..5026198 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ799_RS23060 Protein ID WP_003088112.1
Coordinates 5024977..5025531 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ799_RS23035 (KZ799_23030) 5020544..5021095 + 552 WP_004343115.1 XRE family transcriptional regulator -
KZ799_RS23040 (KZ799_23035) 5021092..5021490 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
KZ799_RS23045 (KZ799_23040) 5021503..5021826 - 324 WP_003102734.1 multidrug efflux SMR transporter -
KZ799_RS23050 (KZ799_23045) 5022157..5022618 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
KZ799_RS23055 (KZ799_23050) 5022623..5024818 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KZ799_RS23060 (KZ799_23055) 5024977..5025531 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KZ799_RS23065 (KZ799_23060) 5025620..5026198 + 579 WP_003114949.1 HD domain-containing protein Toxin
KZ799_RS23070 (KZ799_23065) 5026306..5027493 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KZ799_RS23075 (KZ799_23070) 5027483..5029654 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
KZ799_RS23080 (KZ799_23075) 5029644..5030922 - 1279 Protein_4559 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T211581 WP_003114949.1 NZ_CP080281:5025620-5026198 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T211581 NZ_CP104973:1382152-1382439 [Phyllobacterium zundukense]
ATGGTTGAAAAGTTGATCCCCTATGATCCTGCCGAGGATTTGACGACCGATGACGCTATAGAAGTATTTCTTACCGATGC
CTTCGAGACGGGGGATGCAGCCTATATCGCCAGGGCATTGGGTGTGGTGGCAAGAGCGAAGGGTATGACCAAGATCGCTC
GAAAAACGGGTTTGGCCCGAGAGCAGCTCTATCGTTCCTTAAGTGAAAACGGGAATCCCACTCTCGAAACGACGATGGCT
GTCATGAAGGCGATCGGGTTTCAAATTACCGGCAAGCGCGCGGCATAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211581 WP_003088112.1 NZ_CP080281:5024977-5025531 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211581 NZ_CP104973:1381926-1382159 [Phyllobacterium zundukense]
TTGATCGCATCGCGGTTAGAGCGCCTTGCTTTCGGGCACGCAGGCGATGTGCAACCTGTAGGGCACGGTATTAGTGAACT
GCGAATTCATTACGGTCCCGGATATCGTATCTATTTTCAGAGGCGAGGAGATGTGATCGTAGTTCTCCTCTGTGGTGGTG
ATAAGAGCACGCAGGCAAGGGACATCCGCACAGCGAAACTTTTGGCTGCCGAATGGAGGGAATGGAATGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References