Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4093519..4094443 Replicon chromosome
Accession NZ_CP080281
Organism Pseudomonas aeruginosa strain UNC_PaerCF17

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KZ799_RS19210 Protein ID WP_033979787.1
Coordinates 4094261..4094443 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KZ799_RS29445 Protein ID WP_016561976.1
Coordinates 4093519..4094214 (-) Length 232 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ799_RS19170 (KZ799_19170) 4088765..4089616 - 852 WP_021263391.1 S24 family peptidase -
KZ799_RS19175 (KZ799_19175) 4089716..4089934 + 219 WP_016561979.1 Cro/CI family transcriptional regulator -
KZ799_RS19180 (KZ799_19180) 4089966..4090538 + 573 WP_023096627.1 hypothetical protein -
KZ799_RS29440 4090541..4091425 + 885 WP_034056379.1 hypothetical protein -
KZ799_RS19190 (KZ799_19190) 4091328..4092083 + 756 WP_231280456.1 replication protein P -
KZ799_RS19195 (KZ799_19195) 4092076..4092519 + 444 WP_010793142.1 RusA family crossover junction endodeoxyribonuclease -
KZ799_RS19200 (KZ799_19200) 4092548..4093417 + 870 WP_033979789.1 hypothetical protein -
KZ799_RS29445 4093519..4094214 - 696 WP_016561976.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZ799_RS19210 (KZ799_19210) 4094261..4094443 - 183 WP_033979787.1 type II toxin-antitoxin system HicA family toxin Toxin
KZ799_RS19215 (KZ799_19215) 4094643..4094978 + 336 WP_003119044.1 phage holin, lambda family -
KZ799_RS19220 (KZ799_19220) 4094975..4095592 + 618 WP_023097520.1 glycoside hydrolase family 19 protein -
KZ799_RS29450 4095610..4096041 + 432 WP_170954875.1 hypothetical protein -
KZ799_RS19230 (KZ799_19230) 4096138..4096875 + 738 WP_046688673.1 hypothetical protein -
KZ799_RS19235 (KZ799_19235) 4097090..4097635 + 546 WP_031627904.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4068627..4118195 49568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.85 Da        Isoelectric Point: 11.0775

>T211580 WP_033979787.1 NZ_CP080281:c4094443-4094261 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGGHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGFK

Download         Length: 183 bp

>T211580 NZ_CP080281:c4094443-4094261 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAAGGAGGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAGCCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGTTCAAATGA

Antitoxin


Download         Length: 232 a.a.        Molecular weight: 25958.40 Da        Isoelectric Point: 4.8091

>AT211580 WP_016561976.1 NZ_CP080281:c4094214-4093519 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSASGVAVFCRDLPELNSFGDDREHAIREALDAIETTLSLYVDARKPIPEATPPEEGEHVVHLPSVTVA
KIALWNEMMKRGMRKSDLCKLLGIAQTQGDRLVDFLHTSKMEALESALAALDTKLTVRASYGNNVVKLRYMANTARGRVL
VIPGDADPKALPRQYEWLQEAPCRIEETVDDFEVGARYAMWNVEEAVNAIQSRGYFSFWLETTSGPRSATR

Download         Length: 696 bp

>AT211580 NZ_CP080281:c4094214-4093519 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTTCTGGCGTTGCCGTTTTCTGCAGAGACCTGCCTGAGCT
GAACAGCTTCGGCGACGACCGCGAGCACGCTATCCGCGAAGCGCTGGACGCCATCGAGACGACCCTCTCGCTCTACGTTG
ACGCGCGTAAGCCGATCCCGGAAGCCACTCCGCCAGAAGAAGGCGAACACGTCGTCCACCTGCCATCCGTCACGGTGGCG
AAGATCGCGCTGTGGAACGAGATGATGAAGCGCGGTATGCGCAAGTCGGACCTGTGCAAGCTGCTGGGCATCGCCCAGAC
CCAGGGTGATCGCCTGGTCGACTTTCTTCACACCTCCAAGATGGAGGCGCTGGAGTCGGCGCTTGCCGCACTTGACACGA
AGCTCACCGTCCGCGCCTCTTACGGCAACAACGTGGTCAAGCTCCGGTACATGGCCAATACGGCGCGAGGCCGTGTGCTG
GTCATCCCGGGAGACGCTGACCCGAAGGCTCTCCCCCGTCAGTACGAATGGCTACAGGAAGCACCCTGCAGGATCGAGGA
AACAGTCGACGATTTCGAAGTCGGCGCCAGGTACGCGATGTGGAACGTGGAGGAAGCGGTGAACGCGATCCAGTCACGCG
GCTACTTCAGCTTCTGGCTGGAAACAACGTCAGGCCCCCGAAGCGCCACACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References