Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3305908..3307416 Replicon chromosome
Accession NZ_CP080281
Organism Pseudomonas aeruginosa strain UNC_PaerCF17

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KZ799_RS15250 Protein ID WP_003119682.1
Coordinates 3305908..3306495 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag KZ799_RS15255 Protein ID WP_003091607.1
Coordinates 3306562..3307416 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ799_RS15245 (KZ799_15245) 3302163..3305642 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
KZ799_RS15250 (KZ799_15250) 3305908..3306495 + 588 WP_003119682.1 GNAT family protein Toxin
KZ799_RS15255 (KZ799_15255) 3306562..3307416 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
KZ799_RS15260 (KZ799_15260) 3307513..3309678 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
KZ799_RS15265 (KZ799_15265) 3309853..3311727 + 1875 WP_003117607.1 MFS transporter -
KZ799_RS15270 (KZ799_15270) 3311788..3311997 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T211579 WP_003119682.1 NZ_CP080281:3305908-3306495 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T211579 NZ_CP104972:834503-834886 [Phyllobacterium zundukense]
GTGATCCTCGCGGACACCTCGATCTGGATTGATCATTTTCGTCGTGTTGATGCGGAGCTGCGCAGGATTATTGAAGACGA
CCTCCTACTTTGCCACCCAGCCGTGATCGGTGAGCTGGCGCTTGGCAGCCTTAGGGATCGCGGCAGCGTGATCGCTTTTC
TGGCGGCGCAGCGCGCGGCGGTCGTCGCCACGCACGACGAAGTCATGACAATGATCGATCGCCACAGTCTTTTCAGCATC
GGCATTGGCTACACCGATGCTCACCTGCTGGCATCCGTCCTTCTTGACCAGCGAGCGACCTTATGGACCAGAGACAAGCG
CCTAAGAGCGGCGGCCGAAAAGGCAGGCGCTTCACTGCACCTACCCGTAAATCGTCCGAACTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT211579 WP_003091607.1 NZ_CP080281:3306562-3307416 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT211579 NZ_CP104972:834306-834506 [Phyllobacterium zundukense]
ATGCGATCAACTATTAACCTCGACGATACGCTTATGGAGAAGGCCAGGTTCTTGACCGGTACAAATGAAACAGCGGCCCT
AGTGCGCCAGGCGTTGGAAACGCTTGTCCGTGTGGAGTCCGGAAAGCGCCTCATCGCGCTCGGAGGAACTATGCCCGATG
CCGAGGCAGCTCCGCGCCGCCGGAGCGCAGCAGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References