Detailed information of TA system TA211578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1623383..1623888
• Replicon: chromosome
• Accession: NZ_CP080281
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF17

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: KZ799_RS07390
• Protein ID: WP_003083773.1
• Coordinates: 1623383..1623664 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: KZ799_RS07395
• Protein ID: WP_003083775.1
• Coordinates: 1623661..1623888 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ799_RS07365 (KZ799_07365)	1618634..1619983	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
KZ799_RS07370 (KZ799_07370)	1620032..1620718	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
KZ799_RS07375 (KZ799_07375)	1620819..1621553	+	735	WP_003101224.1	GntR family transcriptional regulator	-
KZ799_RS07380 (KZ799_07380)	1621733..1622143	+	411	WP_003101225.1	aegerolysin family protein	-
KZ799_RS07385 (KZ799_07385)	1622175..1623083	-	909	WP_016561475.1	LysR family transcriptional regulator	-
KZ799_RS07390 (KZ799_07390)	1623383..1623664	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
KZ799_RS07395 (KZ799_07395)	1623661..1623888	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
KZ799_RS07400 (KZ799_07400)	1624064..1624684	-	621	WP_003101226.1	hypothetical protein	-
KZ799_RS07405 (KZ799_07405)	1624785..1625285	+	501	WP_003112629.1	LEA type 2 family protein	-
KZ799_RS07410 (KZ799_07410)	1625358..1625699	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
KZ799_RS07415 (KZ799_07415)	1625781..1627208	-	1428	WP_003083784.1	GABA permease	-
KZ799_RS07420 (KZ799_07420)	1627377..1628870	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T211578 WP_003083773.1 NZ_CP080281:c1623664-1623383 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T211578 NZ_CP104972:c754335-754042 [Phyllobacterium zundukense]
ATGCGTTTTAGCCTTTCTGTCGAAGCGGAAGAAGACATCATTGTCATCACCGAGCAAGGTATCCGCATGTTCGGAACTCT
ACAGGCCAGGCGGTACCATGACGACTTGTTCGCGGTACTTGAACTGATCGCCGCGAATCCCCGAATGGCGCGTGAGCGCG
AAGAGATTTCGCCGCCGGTCAGGATCCATCCGTTCAAAGCCCATCTGATTGTCTGCCGCATCCAAGAGAACGGAACCATT
TTCGTGATTCGAATACGCCATGGACATGAAGATTGGGCCAGCGAGCCTGCTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT211578 WP_003083775.1 NZ_CP080281:c1623888-1623661 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT211578 NZ_CP104972:c754589-754335 [Phyllobacterium zundukense]
ATGGCTACTATGAACGTGTCTCTACCGGATCCAATGAAAGATTGGGTCGAAGCCCAGGCAAGGACCGGGCGATACTCCAA
TGCGAGTGACTATGTGCGCGATCTGATTCGAAGGGACCAAACGCGTAGCGATAAGATTGTTGCCATGCAACGCTTCGTCG
ATGACGGCCTCAAAAGTGGTGTTGGCAGCCGGTCGAAGGACGAGCTCTTCGCTGCGGCTGCCGCGCGCACGGAAACGGCG
CGCGGCAGCAAATAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9