Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 6375396..6375901 Replicon chromosome
Accession NZ_CP080280
Organism Pseudomonas aeruginosa strain UNC_PaerCF20

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag KZ794_RS29460 Protein ID WP_003121619.1
Coordinates 6375620..6375901 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag KZ794_RS29455 Protein ID WP_003083775.1
Coordinates 6375396..6375623 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ794_RS29430 (KZ794_29430) 6370414..6371907 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
KZ794_RS29435 (KZ794_29435) 6372076..6373503 + 1428 WP_003083784.1 GABA permease -
KZ794_RS29440 (KZ794_29440) 6373585..6373926 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KZ794_RS29445 (KZ794_29445) 6373999..6374499 - 501 WP_003101228.1 LEA type 2 family protein -
KZ794_RS29450 (KZ794_29450) 6374600..6375220 + 621 WP_003101226.1 hypothetical protein -
KZ794_RS29455 (KZ794_29455) 6375396..6375623 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
KZ794_RS29460 (KZ794_29460) 6375620..6375901 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
KZ794_RS29465 (KZ794_29465) 6376201..6377109 + 909 WP_023083551.1 LysR family transcriptional regulator -
KZ794_RS29470 (KZ794_29470) 6377141..6377551 - 411 WP_003101225.1 aegerolysin family protein -
KZ794_RS29475 (KZ794_29475) 6377731..6378465 - 735 WP_003117208.1 GntR family transcriptional regulator -
KZ794_RS29480 (KZ794_29480) 6378566..6379252 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KZ794_RS29485 (KZ794_29485) 6379301..6380650 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T211576 WP_003121619.1 NZ_CP080280:6375620-6375901 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T211576 NZ_CP104972:c528640-528071 [Phyllobacterium zundukense]
TTGGGGACTTTCACAGCTTTCTTGGACGCATCGGTTCTCTATCCAGCTCCCTTGCGCGACCTGCTTTTGGAGCTTGCTGT
TTCTGACCTGTATCGCGCCAAATGGTCGAACACAGTGCATGATGAATGGATCAACGCTTTGCTCACAAGCAGGGACGATC
TAACCAGAGAACGGCTCGAGCGGACCCGCCACCTGATGAACGCCCATGTGCGCGACGCGCTTGTTACAGATTTTGATCAA
CTCATTGGCATTCTCCAGTTGCCGGATCCTGATGATCGCCACGTTCTAGCGGCGGCCATCAAGGGGCGGGCTGATTTGAT
CGTTACAGCAAATCTCAAGGACTTTCCCCACAGCCAGCTCGCACCGTGGGGCATTGAAGCCCAACATCCCGATGAATTCC
TAACGCACCAGTTCCACCTTTCGCAGCCGCAGTTTCTGGCCGCCATAAAAGCGGTTCGCTTACGTCTAAAGAACCCGCCG
AAGACGGTCGAAGACTACCTTGATACACTTCGCGCGCAGGGCCTTTTGGCTACAGTCAACGAGATCCAAGCATTTGATCA
GTTCATTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT211576 WP_003083775.1 NZ_CP080280:6375396-6375623 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT211576 NZ_CP104972:c529096-528644 [Phyllobacterium zundukense]
ATGACGGCCGCCCTCACCACAAATCCACCATCCAAAGATGACGTGGAGCTTGCACGCGCATCGGGCCAGCGATTGGCTCC
TTATGCACGCAAAGGACTTGCTTTGACATTTCGCGTTCGTGATGCAGACAACGAAGAAGCTATTGAGCTGCCGGCGGGGG
CCGTGAAGCTGCTTATGGCCGTGCTTGAGGATATGGCATCGGGAAGAGCTGTTACGATCGTCCCGCAGAACGCTGAACTG
ACAACACAGCAAGCCGCTGACGTCCTGAACGTATCGCGTCCGTTTCTAATTGGCCTGTTGGACGAGAGGAAGCTACCATT
CCGCATGGTGGGAACCCATCGCCGTGTTCGTTTCGAAGATGTACTGAACTACAAAGAGGCGATCGACACGGAACGGCGCA
AGGTATTGGGCCAGCTTGCAGCGGAGGCTCAAGAGCTTGGGATGGGATACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References