Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4657503..4659011 Replicon chromosome
Accession NZ_CP080280
Organism Pseudomonas aeruginosa strain UNC_PaerCF20

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag KZ794_RS21485 Protein ID WP_003119682.1
Coordinates 4658424..4659011 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag KZ794_RS21480 Protein ID WP_003119683.1
Coordinates 4657503..4658357 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ794_RS21465 (KZ794_21465) 4652922..4653131 + 210 WP_003115568.1 cold-shock protein -
KZ794_RS21470 (KZ794_21470) 4653192..4655066 - 1875 WP_003117607.1 MFS transporter -
KZ794_RS21475 (KZ794_21475) 4655241..4657406 - 2166 WP_016852624.1 TonB-dependent receptor family protein -
KZ794_RS21480 (KZ794_21480) 4657503..4658357 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
KZ794_RS21485 (KZ794_21485) 4658424..4659011 - 588 WP_003119682.1 GNAT family protein Toxin
KZ794_RS21490 (KZ794_21490) 4659277..4662756 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T211574 WP_003119682.1 NZ_CP080280:c4659011-4658424 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T211574 NZ_CP104971:537260-537652 [Phyllobacterium zundukense]
ATGCTCGATACCAACGCTGTCAGCCTAGCAATCAAGGGAAATGCCGCCACTGTCAAACGCATGGTCGATATCCCAATGGC
ATCAATATGCATCTCTGTTGTCACCGAGGCAGAGCTGCTTTTCGGGCTTGCGAAGCGACCTGCAGCTACAAAGCTCTCCA
GTCGAATTCACGAGTTTCTAAAGCGTGTGAATAGCCTGCCGCTCGACAGCACCGTAGCTGCCCGCTATGGACCATTGCGC
GCACAGCTGGAGCAGCGCGGAAGGGCGATCATAGGGCTAGACTTGTTGATTGCTGCTCACGCAATCGCTGCAAATGCGAT
TTTGGTGTCAAATGATGCAGCGTTCCGCCATGTCGAAGGTCTCCAAGTGGAGGACTGGTCGAAAGATCCCTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT211574 WP_003119683.1 NZ_CP080280:c4658357-4657503 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT211574 NZ_CP104971:536988-537248 [Phyllobacterium zundukense]
ATGACCCAGACGGCAAAGATTTTTACGAATGGGCGCAGTCAAGCAGTGCGCCTTCCTGCAGCCTATCGGTTCGACAGCAG
CGAGGTATTTATTCGCCGTGATGAAGTTACGGGTGATGTCATCCTGTCGAGCAAACCTGATAACTGGGATGGATTTCTCG
CAGCACTTAGAGAAGGAGATGTACCTGCCGATTTCCTTAGCAGGGAAGAGCGCAATCTTTCCGGCAGCGATACAGATCCA
TTTGAGGGTTGGGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References