Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 2818075..2819296 | Replicon | chromosome |
Accession | NZ_CP080280 | ||
Organism | Pseudomonas aeruginosa strain UNC_PaerCF20 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | KZ794_RS13110 | Protein ID | WP_003114949.1 |
Coordinates | 2818075..2818653 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | KZ794_RS13115 | Protein ID | WP_003088112.1 |
Coordinates | 2818742..2819296 (-) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZ794_RS13095 (KZ794_13090) | 2813352..2814629 | + | 1278 | WP_003102743.1 | TolC family protein | - |
KZ794_RS13100 (KZ794_13095) | 2814619..2816790 | + | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
KZ794_RS13105 (KZ794_13100) | 2816780..2817967 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
KZ794_RS13110 (KZ794_13105) | 2818075..2818653 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
KZ794_RS13115 (KZ794_13110) | 2818742..2819296 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
KZ794_RS13120 (KZ794_13115) | 2819454..2821649 | - | 2196 | WP_023082959.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
KZ794_RS13125 (KZ794_13120) | 2821654..2822115 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
KZ794_RS13130 (KZ794_13125) | 2822446..2822769 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
KZ794_RS13135 (KZ794_13130) | 2822782..2823180 | + | 399 | WP_023082958.1 | NADH-quinone oxidoreductase subunit A | - |
KZ794_RS13140 (KZ794_13135) | 2823177..2823728 | - | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T211572 WP_003114949.1 NZ_CP080280:c2818653-2818075 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
>T211572 NZ_CP104967:c904598-904215 [Phyllobacterium sp. A18/5-2]
GTGATACTCGCGGACACCTCGATCTGGATTGATCATTTTCGTCGTGTTGATGCGGAGCTGCGCAGGATTATTGAAGACGA
CCTCCTACTTTGCCACCCAGCCGTGTTCGGTGAGCTGGCGCTTGGCAGCCTTGGGGCTCGCGGCAGCGTGATGGCTTTTC
TGGCGGCGCAGCGCGCGGCGGTCGCCGCCACGCACGACGAAGTCATGACAATGATCAATCGCCACAGTCTTTTCAGCATC
GGCATTGGCTACACCGATGCTCACTTGCTGGCATCCGTCCTTCTTGACCAGCGAGCGACCTTATGGACCAGAGACAAGCG
CCTAAGAGCAGCGGCCGAAAAGGCAGGCGCTTCACTGCACCTACCCGTAAATCGTCCCAACTAA
GTGATACTCGCGGACACCTCGATCTGGATTGATCATTTTCGTCGTGTTGATGCGGAGCTGCGCAGGATTATTGAAGACGA
CCTCCTACTTTGCCACCCAGCCGTGTTCGGTGAGCTGGCGCTTGGCAGCCTTGGGGCTCGCGGCAGCGTGATGGCTTTTC
TGGCGGCGCAGCGCGCGGCGGTCGCCGCCACGCACGACGAAGTCATGACAATGATCAATCGCCACAGTCTTTTCAGCATC
GGCATTGGCTACACCGATGCTCACTTGCTGGCATCCGTCCTTCTTGACCAGCGAGCGACCTTATGGACCAGAGACAAGCG
CCTAAGAGCAGCGGCCGAAAAGGCAGGCGCTTCACTGCACCTACCCGTAAATCGTCCCAACTAA
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT211572 WP_003088112.1 NZ_CP080280:c2819296-2818742 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
>AT211572 NZ_CP104967:c904795-904595 [Phyllobacterium sp. A18/5-2]
ATGCGATCGACTATTAACCTCGACGACACGCTTATGGAGAAGGCTAGGTTGTTGACCGGTACAAATGAAACTGCGGCCCT
AGTGCGCCAGGCGTTGGAAACGCTTGTCCGTGTGGAGTCTGGAAAGCGCCTCATCGCGCTCGGAGGAACTATGCCCGATG
CCGAGGCAGCTCCGCGCCGCCGGAGCGCAGCGGCCAAGTGA
ATGCGATCGACTATTAACCTCGACGACACGCTTATGGAGAAGGCTAGGTTGTTGACCGGTACAAATGAAACTGCGGCCCT
AGTGCGCCAGGCGTTGGAAACGCTTGTCCGTGTGGAGTCTGGAAAGCGCCTCATCGCGCTCGGAGGAACTATGCCCGATG
CCGAGGCAGCTCCGCGCCGCCGGAGCGCAGCGGCCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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