Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2818075..2819296 Replicon chromosome
Accession NZ_CP080280
Organism Pseudomonas aeruginosa strain UNC_PaerCF20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZ794_RS13110 Protein ID WP_003114949.1
Coordinates 2818075..2818653 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZ794_RS13115 Protein ID WP_003088112.1
Coordinates 2818742..2819296 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ794_RS13095 (KZ794_13090) 2813352..2814629 + 1278 WP_003102743.1 TolC family protein -
KZ794_RS13100 (KZ794_13095) 2814619..2816790 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
KZ794_RS13105 (KZ794_13100) 2816780..2817967 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
KZ794_RS13110 (KZ794_13105) 2818075..2818653 - 579 WP_003114949.1 HD domain-containing protein Toxin
KZ794_RS13115 (KZ794_13110) 2818742..2819296 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
KZ794_RS13120 (KZ794_13115) 2819454..2821649 - 2196 WP_023082959.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KZ794_RS13125 (KZ794_13120) 2821654..2822115 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
KZ794_RS13130 (KZ794_13125) 2822446..2822769 + 324 WP_003102734.1 multidrug efflux SMR transporter -
KZ794_RS13135 (KZ794_13130) 2822782..2823180 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
KZ794_RS13140 (KZ794_13135) 2823177..2823728 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T211572 WP_003114949.1 NZ_CP080280:c2818653-2818075 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T211572 NZ_CP104967:c904598-904215 [Phyllobacterium sp. A18/5-2]
GTGATACTCGCGGACACCTCGATCTGGATTGATCATTTTCGTCGTGTTGATGCGGAGCTGCGCAGGATTATTGAAGACGA
CCTCCTACTTTGCCACCCAGCCGTGTTCGGTGAGCTGGCGCTTGGCAGCCTTGGGGCTCGCGGCAGCGTGATGGCTTTTC
TGGCGGCGCAGCGCGCGGCGGTCGCCGCCACGCACGACGAAGTCATGACAATGATCAATCGCCACAGTCTTTTCAGCATC
GGCATTGGCTACACCGATGCTCACTTGCTGGCATCCGTCCTTCTTGACCAGCGAGCGACCTTATGGACCAGAGACAAGCG
CCTAAGAGCAGCGGCCGAAAAGGCAGGCGCTTCACTGCACCTACCCGTAAATCGTCCCAACTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT211572 WP_003088112.1 NZ_CP080280:c2819296-2818742 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT211572 NZ_CP104967:c904795-904595 [Phyllobacterium sp. A18/5-2]
ATGCGATCGACTATTAACCTCGACGACACGCTTATGGAGAAGGCTAGGTTGTTGACCGGTACAAATGAAACTGCGGCCCT
AGTGCGCCAGGCGTTGGAAACGCTTGTCCGTGTGGAGTCTGGAAAGCGCCTCATCGCGCTCGGAGGAACTATGCCCGATG
CCGAGGCAGCTCCGCGCCGCCGGAGCGCAGCGGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References