Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1889500..1890758 Replicon chromosome
Accession NZ_CP080280
Organism Pseudomonas aeruginosa strain UNC_PaerCF20

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag KZ794_RS08760 Protein ID WP_003112528.1
Coordinates 1890003..1890758 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag KZ794_RS08755 Protein ID WP_003086329.1
Coordinates 1889500..1889868 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ794_RS08735 (KZ794_08735) 1885663..1885938 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
KZ794_RS08740 (KZ794_08740) 1885941..1886417 - 477 WP_003112531.1 hypothetical protein -
KZ794_RS08745 (KZ794_08745) 1886496..1888085 + 1590 WP_003125055.1 aldehyde dehydrogenase family protein -
KZ794_RS08750 (KZ794_08750) 1888141..1889427 + 1287 WP_023083139.1 FAD-binding oxidoreductase -
KZ794_RS08755 (KZ794_08755) 1889500..1889868 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
KZ794_RS08760 (KZ794_08760) 1890003..1890758 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
KZ794_RS08765 (KZ794_08765) 1891526..1892887 + 1362 WP_073647918.1 DNA recombination protein RmuC -
KZ794_RS08770 (KZ794_08770) 1893042..1895585 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T211571 WP_003112528.1 NZ_CP080280:1890003-1890758 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T211571 NZ_CP104967:672620-673876 [Phyllobacterium sp. A18/5-2]
ATGACGCATATGCTGGATGTCTATTACAGGCAAGAGAAGGCAGGCGCGCTCAGCCAGGAAGATGATGGCGCGCTCAGCTT
CGCTTACGATGCTGGTTATCTGGGAGGAAGCGAGCCCAGCGCCATCTCCTCTTCCATGCCGTTGCAGGAGGCGGCTTATG
GAGACAGGATCGTTCGCCCATTCTTTTCCGGCCTTCTGCCAGATGAAGGGGCGCGGCAGCGCCTTGCGGGCGCGCTCGGG
ATTTCATCAGGCAATGCCTTTGGCCTTCTAGAGGTCATAGGCGGGGAATGCGCGGGAGCATTATCGCTCTATCCCGCAGG
TGAGGCGCCGCCATCATCGGATGACGATGGCGTTGAAGTTCTGAGCCGGGAGCGGCTAGAGGAAATCCTTGGCAAACTGC
GTGAGCGCCCTCTGTTGGGAGGTGAGGAAGGGGTACGCCTGTCCCTTGCCGGTGCGCAGGACAAGCTTGCTGTCTGTGCT
GAGGGAGAGAATATCGGGCTTGCCAAGGGCGGCCGTCCGACGACCCATATCTTAAAGCCCTTCATTCAGGCCCTCGATGG
TACGGTCGAGAACGAACTGTTCTGCCTGCGCCTCGCGGCGCGGCTGGGGCTTCCCGTGCCCAACGTGGAAATGAGGCACG
GCGCGACTCCGTTCCTGTTGGTCGAGCGCTATGACCGCGCGCGGCATGAAGATGGGACGATCACGCGCCTCCACCAGGAG
GATTTCTGTCAGGCCTTGAGCGTGCCGCCGGAGCTGAAATATGAGGCAGAAGGCGGGCCGGGAACAGAAGCGTCGCTGGC
GCTGATTGGGCGTGCCACCGCGCATCCCGCAGCCGACCGTCTCGGGTTCATCCGCATGCTCATTCTGCATTACCTTGTCG
GAAATGCGGATGCCCACGGTAAGAACTACGCGTTGCTTTACAGCGGCGGGATTCCTGATCTGGCGCCGCTCTACGATGTC
CTTTGCACGGCCGCTTACCCAAGGCTGGACAAAAAGCTCGCCATGGCCATTGGCGGGCGCGCCGTCCCCGACACGATACA
GCTACAGCAATGGCTCACCCTTGTGCCAGATACGCGCGGGGCGCAGCGTCTCCTGGTCAAGGCCATCGCCGAACTCGCAG
GGCGCATCGGCGGTCAAGCCGACGAGCTTCTCGCGGAGTTTGCCGAGGGCGGCATCACCCATGAAATCCTCAAAGTCATT
CGCGGCGTCATAGGGACGCGCGCCGAACATTTGCTGCGCATTATCGAAAAGGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT211571 WP_003086329.1 NZ_CP080280:1889500-1889868 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT211571 NZ_CP104967:672396-672623 [Phyllobacterium sp. A18/5-2]
ATGCAAACGATCATAGATAGTAAGAGCTTTGGACTTCTGATCCGTGCGGAGCGCAAGGCACAGAACCTGACACAGGAGCA
GCTCGCAGGGTTGACCGGGGTTGGGGTGCGTTTCCTGCGCGAGCTTGAAGCCGGGAAGGACAGTTGCCAGATCGGCCGCG
CCCTACAGGTGGCGGCGACCTTAGGGCTGCGTGTTTCCGTCGGCAGTCGTCGGGAGAGCGCGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References